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Use of Liuwei Dihuang Decoction Extract in Treatment of Dementia or Cognitive Impairment

A technology of Liuwei Dihuang decoction and extract, applied in the field of Liuwei Dihuang decoction extract, can solve the problems of poor cognitive function improvement effect of patients, liver damage, no evidence of dementia or cognitive dysfunction improvement or therapeutic effect, etc. The effect of object recognition memory

Active Publication Date: 2017-10-27
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the curative effect and safety of non-traditional antipsychotic drugs have been improved compared with traditional antipsychotic drugs, side effects such as extrapyramidal system, drowsiness, excessive sedation and agranulocytosis may also occur, and clozapine has obvious anticholesterol Alkaliergic effect and therefore not suitable for dementia patients
② Emotional regulation drugs, whose indications are agitation and aggression associated with dementia, but will produce side effects such as rash, sedation, inability to move, liver damage, etc., and have poor effect on improving cognitive function of patients
④ Acetylcholinesterase inhibitors, more and more clinical trials have proved that acetylcholinesterase inhibitors can not only improve cognitive function, but also be effective for behavioral and mental symptoms associated with mild and moderate AD patients, but they can only Delaying the course of the disease does not fundamentally improve the cognitive function of dementia patients
[0007] Traditional Chinese medicine is widely trusted by patients because of its small side effects and its ability to treat both symptoms and root causes. As a representative prescription, Liuwei Dihuang Fang has been passed down for thousands of years. It has significant effects such as nourishing yin and kidney, enhancing immunity, and anti-aging, but there is no strict clinical research to prove it. It has a therapeutic effect on dementia or cognitive impairment
As for the extract of Liuwei Dihuang Decoction, there is no proof that it can improve or treat dementia or cognitive dysfunction

Method used

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  • Use of Liuwei Dihuang Decoction Extract in Treatment of Dementia or Cognitive Impairment
  • Use of Liuwei Dihuang Decoction Extract in Treatment of Dementia or Cognitive Impairment
  • Use of Liuwei Dihuang Decoction Extract in Treatment of Dementia or Cognitive Impairment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Example 1. The effect of Liuwei rehmanthin sugar of the present invention on the object recognition and memory ability of rapid aging model mice influences

[0056] 1. Materials

[0057] 1.1 Animals: rapid aging model mouse SAMP8 (clean grade) and anti-rapid aging model mouse SAMR1 (clean grade), weighing 29-33 g.

[0058] 1.2 Reagents and drugs: donepezil hydrochloride; memantine hydrochloride; Liuwei rehmanthin.

[0059] 1.3 Experimental equipment: The size of the custom-made test box is 30×30×30cm (width×length×height), the box body is black opaque plexiglass, and the bottom of the box is transparent plexiglass. The video of mice exploring objects was collected by Anymaze software.

[0060] 2. Method

[0061] 2.1 Administration method

[0062] According to the body weight of the mice, the mice were divided into five groups by random grouping: normal control group (SAMR1 type normal mice), model control group (SAMP8 type sporadic spontaneous dementia model mice...

Embodiment 2

[0076] Example 2. The effect of Liuwei rehmanthin sugar of the present invention on the passive avoidance response ability of rapid aging model mice influences

[0077] 1. Materials

[0078] 1.1 Animals: Same as Example 1.

[0079] 1.2 Reagents and medicines: Same as Example 1.

[0080] 1.3 Experimental equipment: jumping platform device (DTT-2, Chinese Academy of Medical Sciences), the box body is a plastic cuboid with an open top cover and opaque sides, the size is 22×28×36cm (width×length×height), and the bottom surface is a stainless steel grid , The grid spacing is 1.5cm (36v voltage can be passed). The platform is a cuboid plastic foam: 8×8×2.5cm (width×length×height). Place the platform in the center of the box, 7 and 10cm away from both sides of the box.

[0081] 2. Method

[0082] 2.1 Administration method: Same as Example 1.

[0083] 2.2 Platform jump experiment

[0084] Before the experiment, test the experimental equipment and observe whether its working...

Embodiment 3

[0095] Example 3. The effect of Liuwei rehmanthin sugar of the present invention on the spatial learning and memory ability of rapid aging model mice influences

[0096] 1. Materials

[0097] 1.1 Animals: Same as Example 1.

[0098] 1.2 Reagents and medicines: Same as Example 1.

[0099] 1.3 Experimental equipment: Morris water maze (DNS-2, Chinese Academy of Medical Sciences) includes the following three parts: the experimental device is composed of the maze body (pool), video acquisition system, related graphics processing software and computer: the diameter of the palace body is 100cm, The maze wall is 30cm above the water surface, and the safety platform (circular, 10cm in diameter, with a rough surface for animals to grasp) is hidden under the water surface of 1-2cm, and the water temperature is 23°C±3°C.

[0100] 2. Method

[0101] 2.1 Administration method: Same as Example 1.

[0102] 2.2 Morris water maze experiment

[0103] Before the experiment, the pool was...

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Abstract

The present invention relates to the use of the extract of Liuwei Dihuang Decoction, in particular to the use of the extract of Liuwei Dihuang Decoction in the preparation of medicines for preventing and / or treating dementia or cognitive dysfunction. The Liuwei Dihuang Decoction extract of the present invention can significantly improve the object recognition and memory ability, spatial learning and memory ability, passive avoidance response ability and active avoidance response ability of dementia model mice, and can be used to prevent and / or treat dementia or cognitive dysfunction, It has a good application prospect.

Description

technical field [0001] The present invention relates to the use of the extract of Liuwei Dihuang Decoction, in particular to the use of the extract of Liuwei Dihuang Decoction in the preparation of medicines for preventing and / or treating dementia or cognitive dysfunction. Background technique [0002] Dementia is a syndrome caused by brain diseases, which is usually chronic and progressive in nature, and in the case of clear consciousness, there will be a variety of higher cortical dysfunction, usually accompanied by impairment of cognitive function, occasionally emotional control and A decline in social behavior or motivation is prodromal. It is distinct from congenital mental retardation and usually requires cognitive impairment to persist for at least 6 months. Mild cognitive impairment (MCI) specifically refers to those who have memory or cognitive function decline but do not meet the dementia standard. s Disease (AD), the annual conversion rate is 10 times that of th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61P25/28
Inventor 张永祥周文霞程肖蕊王健辉曾菊徐一冉张小锐刘港程军平
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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