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Extraction separation method of chromone glycoside compound and application of chromone glycoside compound in preparation of analgesic anti-inflammatory medicine

The technology of a chromone glycoside and a separation method is applied in the application field of preparing analgesic and anti-inflammatory drugs, and can solve the problems of adrenal cortex function decline, inability to stop the drug, drug dependence and the like, and achieve the effect of good application prospect.

Active Publication Date: 2015-04-08
广东省中药研究所
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although steroidal anti-inflammatory drugs can be used for the treatment of inflammation, the use of hormones will cause drug dependence and cannot be discontinued in the short term, and can cause adrenal cortical function decline, induce ulcers, mental disorders and other serious side effects

Method used

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  • Extraction separation method of chromone glycoside compound and application of chromone glycoside compound in preparation of analgesic anti-inflammatory medicine
  • Extraction separation method of chromone glycoside compound and application of chromone glycoside compound in preparation of analgesic anti-inflammatory medicine
  • Extraction separation method of chromone glycoside compound and application of chromone glycoside compound in preparation of analgesic anti-inflammatory medicine

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Embodiment

[0032] Liquidambar mistletoe glycoside (the chromone glycoside compound extracted by the present invention, named after liquidambar mistletoe glycoside) extraction and separation technical steps

[0033] About 5 kg of the whole plant of sweetgum mistletoe was chopped, extracted twice by cold immersion in 95% ethanol, the extract was concentrated under reduced pressure until it had no alcohol smell, and extracted with petroleum ether and EtOAc in turn to obtain 200 g of petroleum ether extract, EtOAc extract 300g, take EtOAc extract 300g, carry out normal pressure silica gel column chromatography, use petroleum ether-EtOAc gradient elution, combine petroleum ether-EtOAc (25:1), (20:1), (15:1), ( 10:1), (5:1), (3:1) eluted fractions (A, B, C, D, E, F), F fractions were separated by silica gel 40 column chromatography, after repeated separation and purification, Recrystallized to obtain liquidambar mistletoside.

[0034] Structural identification example:

[0035] Chemical Stru...

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Abstract

The invention discloses an extraction separation method of a chromone glycoside compound and application of the chromone glycoside compound in preparation of an analgesic anti-inflammatory medicine. The extraction separation method of the chromone glycoside compound comprises the following steps: 1) chopping a viscum liquiddambaricolum hayata total plant, carrying out cold-soaked extracting with ethanol, carrying out reduced pressure concentration on an extracting solution until no ethanol flavour exists, and extracting by utilizing petroleum ether and EtOAc sequentially, so as to obtain petroleum ether extract and EtOAc extract; and 2) taking the EtOAc extract, and carrying out separation and purification, thus obtaining the chromone glycoside compound. A structure formula of the chromone glycoside compound is described in the specification. The chromone glycoside compound can be applied to preparation of the analgesic anti-inflammatory medicine. A pharmaceutical composition containing the chromone glycoside compound is composed of the chromone glycoside compound and pharmaceutical materials. The chromone monomeric compound is extracted and separated from a viscum liquiddambaricolum hayata natural product and has good application prospect in preparation of the analgesic anti-inflammatory medicine.

Description

technical field [0001] The invention relates to an extraction and separation method of chromone glycosides and its application in the preparation of analgesic and anti-inflammatory drugs. Background technique [0002] Anti-inflammatory and analgesic drugs are indispensable drugs for the treatment of colds, rheumatoid diseases, rheumatoid arthritis and other rheumatic diseases, and are also drugs for eliminating pain and other diseases caused by various exogenous factors. It is more widely used in cold regions and winter in our country. There are two types of steroids and non-steroids. The former is an analogue of the adrenocortical hormone cortisone, such as prednisone, prednisolone and so on. Non-steroidal anti-inflammatory analgesics such as indole (Yantongjing, indomethacin, etc.) site, thereby achieving anti-inflammatory and analgesic effects. [0003] Steroidal anti-inflammatory drugs can be used to treat rheumatoid arthritis and other inflammations, and non-steroid...

Claims

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Application Information

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IPC IPC(8): C07H17/07C07H1/08A61K31/7048A61P29/00
CPCA61K9/0031A61K9/02A61K9/146A61K9/2054A61K9/4866C07H1/08C07H17/07
Inventor 杨燕军沙聪威聂阳何盛江曾庆钱陈梅果
Owner 广东省中药研究所
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