Pharmaceutical composition comprising olodaterol and ciclesonide and application thereof

A technology of olodaterol and ciclesonide, which is applied in the treatment of diseases such as chronic obstructive pulmonary disease or asthma, and can solve the problems of increasing economic burden

Inactive Publication Date: 2015-04-29
段希福
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, COPD imposes a significant

Method used

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  • Pharmaceutical composition comprising olodaterol and ciclesonide and application thereof
  • Pharmaceutical composition comprising olodaterol and ciclesonide and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment l

[0027] Embodiment 1, powder spray table 1

[0028] Numbering

[0029] Accurately weigh olodaterol hydrochloride and ciclesonide (average particle size 1-5 μm) of prescription quantity micronization, take dried and micronized lactose, mix with the above-mentioned powder, then fill the powder into the can Make powder mist in the machine.

Embodiment 2

[0030] Embodiment 2, powder spray Table 2

[0031] Numbering

[0032] Accurately weigh olodaterol hydrochloride and ciclesonide (average particle size 1-5 μm) of prescription quantity micronization, take dried and micronized lactose, mix with the above-mentioned powder, then fill the powder into the can Make powder mist in the machine.

Embodiment 3

[0033] Embodiment 3, powder spray Table 3

[0034] Numbering

[0035] Accurately weigh olodaterol hydrochloride and ciclesonide (average particle size 1-5 μm) of prescription quantity micronization, take dried and micronized lactose, mix with the above-mentioned powder, then fill the powder into the can Make powder mist in the machine.

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PUM

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Abstract

The invention discloses a pharmaceutical composition comprising olodaterol or pharmaceutically acceptable salts thereof and ciclesonide. The composition can be prepared into respirable spray, aerosol or powder aerosols. The pharmaceutical composition has a synergistic effect, can reduce adverse reactions, is an ideal measure for rapidly relieving asthma and various COPD acute attacks, is an important treatment means of avoiding bronchial spasm and improving anoxia and is easy and convenient to operate, safe and reliable.

Description

technical field [0001] The present invention relates to olodaterol or a pharmaceutically acceptable salt thereof combined with inhaled ciclesonide pharmaceutical composition for the treatment or prevention of respiratory diseases or their symptoms, especially those diseases accompanied by obstruction or inflammation such as chronic obstruction Treatment of chronic pulmonary disease (COPD) or asthma. Background of the invention [0002] Bronchial asthma, affecting up to 10% of individuals in industrialized countries, is characterized by bronchoconstriction, chronic bronchitis, airway hyperresponsiveness, and mucosal edema. Airway remodeling and altered noncholinergic, nonadrenergic neurotransmission can cause irreversible airway obstruction and reduced lung function. Bronchitis Asthma has emerged over the past 20 years as a major public health problem worldwide. Although data suggest that current asthma treatments have resulted in limited reductions in mortality, it continu...

Claims

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Application Information

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IPC IPC(8): A61K31/538A61P11/06A61P11/00A61P11/02A61K31/58
CPCA61K31/538A61K31/58A61K2300/00
Inventor 段希福
Owner 段希福
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