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Application of gamma-aminobutyric acid or gamma-aminobutyric acid receptor stimulant in preparation of respiratory rhythm regulation medicines

An aminobutyric acid receptor and respiratory rhythm technology, which can be used in drug combinations, respiratory diseases, liquid delivery, etc., to solve problems such as diaphragm fatigue, insufficient breathing and ventilation, and unsatisfactory improvement effects, and achieve slow breathing rate and uniform breathing. , the effect of avoiding apnea

Inactive Publication Date: 2015-06-24
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, continuous stimulation of the phrenic nerve can lead to fatigue of the diaphragm. After a long period of time, the respiratory volume will decrease, which will still cause hypoventilation, which is not ideal for the improvement of the previous symptoms.

Method used

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  • Application of gamma-aminobutyric acid or gamma-aminobutyric acid receptor stimulant in preparation of respiratory rhythm regulation medicines

Examples

Experimental program
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Effect test

Embodiment 1

[0031] The application of gamma-aminobutyric acid receptor agonists in the preparation of drugs for regulating respiratory rhythm specifically comprises the following steps:

[0032] Mixing muscimol and deionized water to prepare a mixed solution is the drug for regulating respiratory rhythm, wherein the concentration of muscimol is 0.3 μg / μl. C57 / BL6 mice were anesthetized with anesthesia and fixed on a stereotaxic apparatus. The scalp was cut, the position of the anterior nucleus of the thalamus was determined according to the brain stereotaxic atlas, and a hole was drilled. Electrodes are inserted into the diaphragm to monitor breathing changes. The drug for regulating respiratory rhythm was injected into the anterior nucleus of the mouse thalamus. Different concentrations of isoflurane gas were anesthetized throughout the experiment to maintain the level of anesthesia under light anesthesia.

[0033] figure 1 It is a schematic diagram of the respiratory rate measured a...

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Abstract

The embodiment of the invention provides an application of gamma-aminobutyric acid or a gamma-aminobutyric acid receptor stimulant in the preparation of respiratory rhythm regulation medicines. The respiratory rhythm regulation medicines react with a gamma-aminobutyric acid rector on glutamatergic neuron in nucleus anterior thalami to effectively alleviate the breathing frequency in order to make the breath uniform; and the medicines can effectively improve tidal breathing, sighing breath and other unstable respiratory rhythm related diseases, can control body to stably intake a proper amount of oxygen to avoid too much oxygen and too less carbon dioxide, guarantee excitement keeping of the respiratory center, prevent an apnoea phenomenon, and are safe and reliable.

Description

technical field [0001] The invention relates to the application of gamma-aminobutyric acid or gamma-aminobutyric acid receptor agonist in the preparation of drugs for regulating respiratory rhythm. Background technique [0002] Breathing is a kind of rhythmic movement. At present, the study believes that the breathing rhythm is produced by the respiratory nerve cell group in the respiratory center, participates in the regulation and improvement of the breathing rhythm, and realizes the normal breathing movement of the body together. Due to organ damage such as heart and lung failure, tracheal blockage, pneumothorax, high cerebral pressure and reduced sensitivity to carbon dioxide, etc., the respiratory rhythm is damaged, and shallow and fast breathing, deep and slow breathing, apnea, tidal breathing, Sighing breathing, etc., can lead to serious consequences such as respiratory acidosis, alkalosis, respiratory arrest and death. In traditional treatment methods, the main targ...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/42A61K9/10A61K9/107A61P11/16
Inventor 张奕王立平李娟蔚鹏飞任锋孙鹏鲁艺刘磊
Owner SHENZHEN INST OF ADVANCED TECH
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