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SNP marker relevant to asthma pathogenesis risk factor and application of SNP marker

A technology for risk and asthma, which is applied in the application field of preparing a diagnostic reagent for the risk of asthma onset, can solve problems such as unclear genetic patterns, and achieve the effects of being beneficial to clinical promotion, low cost, and low equipment requirements.

Inactive Publication Date: 2015-06-24
CHANGZHOU NO 2 PEOPLES HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Over the years, scholars at home and abroad have discussed the pathogenesis and development mechanism of asthma from different perspectives. From the perspective of molecular genetics, asthma is a group of clinical syndromes with genetic susceptibility involving multiple genes, and its heritability is as high as 36% to 79%. Gene-gene and gene-environment interactions predispose some individuals to asthma susceptibility, but the exact pattern of inheritance remains unclear

Method used

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  • SNP marker relevant to asthma pathogenesis risk factor and application of SNP marker
  • SNP marker relevant to asthma pathogenesis risk factor and application of SNP marker
  • SNP marker relevant to asthma pathogenesis risk factor and application of SNP marker

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Embodiment 1

[0029] 1. Research object

[0030] From January 2011 to May 2013, 462 adult patients with asthma were continuously recruited in the Respiratory Clinic of the Second Affiliated Changzhou Hospital of Nanjing Medical University. The control group was 398 healthy people with no family history of atopy and asthma and normal lung function.

[0031] Asthma was diagnosed according to the 2010 edition of the Global Initiative for Asthma Prevention and Control Initiative diagnostic criteria and divided into intermittent attacks (level 1), mild persistent (level 2), moderate persistent (level 3), and severe persistent (level 4) according to severity. All patients with asthma have a history of asthma for at least one year and meet one of the following criteria: ①Peak expiratory flow (PEF)≥20%; ②FEV1 increases ≥12% after inhaling a short-acting β2 receptor agonist for 10 to 20 minutes, and absolute Value ≥ 200ml; ③ 5 to 15 minutes after exercise, FEV1 decreased by ≥ 15% or PEF decreased b...

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Abstract

The invention relates to an SNP (Single Nucleotide Polymorphism) marker and an application of the SNP marker, in particular to an SNP marker relevant to an asthma pathogenesis risk factor, a primer pair and a reagent kit for detecting the SNP marker, and an application of the SNP marker in preparing a diagnostic reagent for the asthma pathogenesis risk factor. When the site genotype of the SNP marker rs352140 is homozygous TT, a detected sample contains an asthma protection factor. The SNP marker rs352140 provides a reliable and sensitive mode for clinically evaluating the asthma pathogenesis risk factor.

Description

technical field [0001] The present invention relates to SNP markers and applications thereof. Specifically, the present invention relates to SNP markers related to the risk of developing asthma, primer pairs and kits for detecting the aforementioned SNP markers, and the aforementioned SNP markers are used in the preparation of diagnostic reagents for the risk of developing asthma Applications. Background technique [0002] Bronchial asthma (asthma for short) is a common and frequently-occurring disease characterized by chronic away inflammation and away remodeling. It is estimated that 10% of the world's population suffers from asthma, which accounts for 1% to 2% of total health care expenditure. In recent years, both in developed and developing countries, the morbidity and mortality of asthma have been increasing rapidly year by year, and asthma has become a serious global public health problem. The etiology and pathogenesis of asthma are still unclear. Over the years, d...

Claims

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Application Information

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IPC IPC(8): C12Q1/68C12N15/11
CPCC12Q1/6883C12Q2600/156
Inventor 张倩
Owner CHANGZHOU NO 2 PEOPLES HOSPITAL
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