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Method of catalytic synthesis of Policosanol ester by using ionic liquid

A technology of ionic liquid and pliol ester, which is applied in the field of ionic liquid catalytic synthesis of pliol ester, can solve the problems of low bioavailability, less side reactions, and poor oil solubility, and achieve improved oil solubility, less side reactions, easy separation effect

Inactive Publication Date: 2015-09-16
JIANGSU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the disadvantages of pletil alcohol, such as high melting point, poor oil solubility and low bioavailability, the present invention develops a synthetic method of pletic alcohol ester with mild reaction conditions, few side reactions, easy separation, and environmental protection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Weigh 8.2 g of plicosanol (90.2% octacosanol, 6.2% triacontanol and 3.5% hexacosanol), and place 4.0 g of lauric acid in the reaction flask, and control the temperature of the oil bath at 150 o C. Turn on magnetic stirring, add 0.61 g of ionic liquid 1-propylsulfonic acid-3-methylimidazolium bisulfate after the sample is melted, inject nitrogen gas, and start timing. After reacting for 0.5 h, the heating was stopped, and the sample was taken out after cooling to obtain the crude pletil alcohol ester, which was separated to obtain the pure pletil alcohol fatty acid ester. Through high-performance liquid chromatography analysis, the conversion rate of pliol laurate was 98.8%.

Embodiment 2

[0022] Weigh 8.7 g of prixol (99% triacontanol) and 59.2 g of methyl oleate into the reaction flask respectively, and control the temperature of the oil bath at 30 o C. Turn on magnetic stirring, add 0.034 g of ionic liquid 1-butylsulfonic acid-3-methylimidazolium p-toluenesulfonate after the sample is melted, inject nitrogen gas, and start timing. After reacting for 10 h, the heating was stopped, and the sample was taken out after cooling to obtain the crude pletil alcohol ester, which was separated to obtain the pure pletil alcohol fatty acid ester. Analysis by high performance liquid chromatography showed that the conversion rate of pletil alcohol oleate was 97.2%.

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Abstract

The invention disclose a method of catalytic synthesis of Policosanol ester by using ionic liquid, belonging to the field of foods, medicines, chemical industry, cosmetics and the like. According to the method, Policosanol aliphatic ester is synthesized from Policosanol serving as a raw material and fatty acid (or aliphatic ester) serving an acyl donator under the catalytic function of ionic liquid. The method has the advantages of rapid reaction, mild condition, few side reactions, easy separation, environmental friendliness and the like.

Description

technical field [0001] The invention relates to a method for catalyzing and synthesizing pliol esters by ionic liquids, and belongs to the technical fields of food, medicine, chemical industry, cosmetics and the like. Background technique [0002] Pulicol is a class of naturally occurring monohydric higher fatty alcohols, mainly including octacosanol, triacontanol, hexacosyl alcohol, etc., of which octacosanol has the highest content. Polyol is composed of hydrophobic hydrocarbon group and hydrophilic hydroxyl group, and mainly exists in natural products such as rice bran wax, cane wax, wheat germ oil, beeswax and insect wax. [0003] Pulicol is a world-recognized functional anti-fatigue substance with extremely high safety. It is reported that the safety of octacosanol in pliol is higher than that of table salt, and the LD in mice 50 is 18000 mg / Kg, while the LD of table salt 50 It is 3000 mg / Kg. In recent years, studies have found that pliol has many important phys...

Claims

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Application Information

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IPC IPC(8): C07C69/24C07C69/58C07C67/08
CPCC07C67/08C07C69/24C07C69/58
Inventor 何文森司晓静余欢张金库李志明
Owner JIANGSU UNIV
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