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Internal extraction electro-spray ionization source and mass spectrometry method thereof

An electrospray ionization source and mass spectrometry analysis technology, applied in the field of analytical chemistry, can solve the problems of differences in the internal structure of tissue samples, easy to change samples, complex analysis methods and device operation, etc., to ensure stability and reliability, and expand applications. Range, easy operation

Inactive Publication Date: 2015-10-07
EAST CHINA UNIV OF TECH +1
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Problems solved by technology

[0004] The invention provides an internal extraction electrospray ionization source and its mass spectrometry analysis method, which solves the technical problems that the analysis methods and devices in the prior art are complicated to operate, easy to change samples, and easily affected by differences in the internal structure of tissue samples

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  • Internal extraction electro-spray ionization source and mass spectrometry method thereof
  • Internal extraction electro-spray ionization source and mass spectrometry method thereof
  • Internal extraction electro-spray ionization source and mass spectrometry method thereof

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Embodiment Construction

[0019] In order to make the above objects, features and advantages of the present invention more comprehensible, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0020] Embodiments of the present invention provide an internal extraction electrospray ionization source device, such as figure 1 , Figure 1A , figure 2 , Figure 2A , image 3 As shown, it is composed of a sampler handle 11, a quantitative sampler 12, a capillary holder 13, a holder inner sleeve 14, an extractant capillary 15, a hand-twist joint 16 and an extractant channel 17, and the sampler handle 11 is connected to a quantitative The sampler 12 constitutes a sampling device. The quantitative sampler 12 , the capillary holder 13 , the inner sleeve of the holder 14 , the extractant capillary 15 and the fingertight joint 16 are sequentially connected and connected with the extractant channel 17 .

[0021] Wherein, the sam...

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Abstract

The invention relates to the field of analytical chemistry, and discloses an internal extraction electro-spray ionization source and a mass spectrometry method thereof. The internal extraction electro-spray ionization source includes a sampler handle 11, a quantification sampler 12, a capillary mounting fixture 13, a mounting fixture inner sleeve 14, an extractant capillary tube 15, a hand-screw joint 16, and an extractant channel 17. The sampler handle 11 and the quantification sampler 12 form a sampling device, the quantification sampler 12, the capillary mounting fixture 13, the mounting fixture inner sleeve 14, the extractant capillary tube 15, and the hand-screw joint 16 are sequentially connected and are connected with the extractant channel 17. The stability and reliability of the analysis result can be guaranteed. An electro-spray nozzle is arranged in the ionization source, so that the electrospray can be directly formed after sampling, the operation is simple, and the influence caused by differences of tissue sample lines or blood vessels can be prevented. The internal extraction electro-spray ionization source and the mass spectrometry method thereof improve the iEESI-MS stability, quantification capability, and analysis speed, and expand the iEESI-MS application range.

Description

technical field [0001] The invention relates to the field of analytical chemistry, in particular to an internal extraction electrospray ionization source and a mass spectrometry analysis method thereof. Background technique [0002] Mass spectrometry (MS) technology is a universal method with high sensitivity, good specificity and fast response speed among many modern analytical testing technologies. For the vast majority of mass spectrometers, it only takes milliseconds from the generation of analyte ions to the acquisition of ion response signals. The development of soft ionization technology ion sources such as closed structure ESI makes mass spectrometry analysis of macromolecules under normal pressure a Possibly, but most of the mass spectrometry instruments currently equipped in laboratories complete the qualitative and quantitative analysis of an actual sample (such as a specific protein in a tissue sample), and it is necessary to extract and purify the sample tissue ...

Claims

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Application Information

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IPC IPC(8): H01J49/10G01N27/62G01N27/626
Inventor 陈焕文周炜刘坤魏益平朱亮徐建军王志豪
Owner EAST CHINA UNIV OF TECH
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