33 results about "Extractive electrospray ionization" patented technology

An apparatus and method for direct analysis of continuous-flow liquid samples by desorption electrospray ionization-mass spectrometry (DESI-MS) including a sample stage that is adapted to receive a liquid sample and a nebulizing ionizer that is configured to generate a charged, nebulized solvent and thereby desorb at least a portion of the liquid sample from the sample stage.

The invention discloses an adjustable device used for an extractive electrospray ionization source. The adjustable device mainly includes a universal interface device, a base, a Y-direction adjustment device, an electrospray channel nozzle parameter adjustment device, and a sample channel nozzle parameter adjustment device. The Y-direction adjustment device is capable of adjusting the heights of an electrospray channel nozzle and a sample channel nozzle. The sample channel nozzle parameter adjustment device and the electrospray channel nozzle parameter adjustment device are capable of adjusting an angle Alpha of the sample channel nozzle and a mass spectrometer sample inlet port, a distance a between the sample channel nozzle and the mass spectrometer sample inlet port, an angle Beta between the electrospray channel nozzle and the sample channel nozzle and a distance b between the electrospray channel nozzle and the sample channel nozzle. The device is applicable to researches of a relation between specific parameters and a signal intensity in a mass spectrometry technology of different forms of samples such as liquid, aerosol, solid surface and viscous samples and the like and particularly suitable for real-time online monitoring of liquid samples.

The present invention relates to electrospray ionization (ESI) at atmospheric pressure coupled with a mass spectrometer, in particular to a special kind of micro-electrospray with liquid flows in the range of 0.1 to 100 microliters per minute. The invention describes the use of an off-axis pre-entrance channel in an ESI ion source to prevent particulate matter with higher inertia than the (charged) gas molecules, such as droplets, from entering the mass spectrometer. The elimination of the particulate matter improves the quantitative precision of an LC / MS bioassay, minimizes the contamination of the mass spectrometer and improves the robustness for high throughput assays.

The invention discloses an MRESI (multichannel rotating electrospray ionization) mass spectrometric analysis ion source. The ion source comprises a pedestal, a stepping motor, a coupling part, a voltage conducting part, a rear support part, a rear-end bearing, a middle shaft, a front support part, a front-end bearing, a spraying needle fixed part, spraying needles and a sample platform, wherein the pedestal supports a whole set of device, and a rotor of the stepping motor and the middle shaft are coaxial; the voltage conducting part is provided with at least one conductive contact, and the spraying needles are communicated with external voltage in an electric conductance manner through wires; the front support part is sleeved on the middle shaft and the spraying needle fixed part through the front-end bearing, the rear support part is sleeved on the middle shaft through the rear-end bearing so as to support on a coaxial direction along a revolving part of the stepping motor; the left end of the middle shaft is connected with the stepping motor through the coupling part so as to transfer the rotation to connect with the spaying needle fixed part of the right end of the middle shaft; and the spraying needle fixed part is provided with multiple grooves used for installing the spraying needles, and each spraying needle is mutually communicated with an outer placing injector through an individual pipeline. The device provided by the invention has the advantages of being capable of improving ionization efficiency, enhancing stability of mass spectrometric detection signals, being used for researching gas phase among different sprayings or liquid phase reactions as well as the detection of polycomponent of complicated samples or full component.

The invention relates to the field of analytical chemistry, and discloses an internal extraction electrospray ionization source and a mass spectrometry analysis method thereof. The internal extraction electrospray ionization source consists of a sampler handle 11, a quantitative sampler 12, a capillary holder 13, and an inner sleeve of the holder. Tube 14, extractant capillary 15, hand twist joint 16 and extractant passage 17 constitute, described sampler handle 11 and quantitative sampler 12 constitute sampling device, quantitative sampler 12, capillary tube holder 13, holder inner casing 14 , the extractant capillary 15 and the thumb joint 16 are sequentially connected and connected with the extractant passage 17. The invention guarantees the stability and reliability of the analysis results. The ionization source device has a built-in electrospray nozzle, which can be directly used to form electrospray after sampling, which is easy to operate and eliminates the influence caused by differences in texture or blood vessels of tissue samples. The invention improves the stability, quantitative ability and analysis speed of iEESI-MS, and expands the application range of iEESI-MS.

The invention relates to an electrospray extraction ionization-mass spectrum (EESI-MS) rapid detection method for alkaloid in lotus seeds, belongs to the technical field of analysis, and particularly relates to a rapid determination method for alkaloid in lotus seeds. The method comprises the following steps: processing a sample, processing a standard product, detecting by EESI-MS, drawing a standard curve, and calculating the concentration of alkaloid in a sample. The method provided by the invention is rapid and accurate without complex sample pretreatment, not only can be used for rapidly identifying the alkaloid in a complex matrix sample, but also can effectively differentiate lotus seed samples with different aging degrees by combining with chemometrics.

The invention discloses a multichannel rotary extractive electrospray ionization mass spectrometry ion source. The multichannel rotary extractive electrospray ionization mass spectrometry ion source comprises an injector mounting part, at least two injector fixing parts, a spraying device mounting part, a metal ring, an insulating ring, a voltage conducting part, a front end support part, a front end connecting part, a spraying device fixing part, at least two ion source mounting parts, at least two ion source fixing parts, a spraying device, at least two spraying needles, a motor transmission part, a bearing, a motor, an injecting pump and the like. According to the ion source, the spraying needles are driven by a stepper motor to rotate to ensure that sprayed mists (electric mist or electroneutral mist) are mixed uniformly, so the ionization efficiency is improved, the strength and stability of mass spectrum signals are improved, and multicomponent or all components in a sample can be analyzed simultaneously and used for researching sample extraction or a gaseous phase / liquid phase reaction among different mists.

The invention belongs to the field of analysis and testing, and discloses a method for directly detecting chloramphenicol in honey by using ND-EESI-MS (neutral desorption-extractive electrospray ionization mass spectrometry). The method comprises the following steps: (1) preparing marked honey; (2) preparing a sample; (3) detecting by using the ND-EESI-MS; (4) selecting the secondary characteristic fragment ions m / z257 of m / z321 to perform quantitative analysis so as to obtain the amount of chloramphenicol. By using the method, the chloramphenicol in the honey can be rapidly detected and identified without pretreatment or chromatographic separation on the sample to be tested, and the defects that in the prior art, the detection steps are complex, and a long time is consumed are overcome.

The invention belongs to the technical field of detection and discloses a method for directly detecting five kinds of chemical pollutants in propolis by electrospray extraction ionization mass spectrometry. The invention comprises the following steps: 1) preparation of standard solution; 2) preparation of propolis tincture; 3) preparation of standard propolis tincture; 4) electrospray extraction ionization mass spectrometry detection; 5) qualitative analysis; 6) quantitative analysis. The detection method of the invention has less sample consumption, fast analysis speed, and can realize high throughput and on-line detection. Direct analysis and detection of common propolis chemical pollutants without complicated sample pretreatment, and the detection time of a single sample is less than 1min. Non-toxic and non-polluting to products, operators and working environment; high sensitivity. The invention does not require complicated pretreatment of the sample to be tested, can withstand the influence of the complex matrix of propolis, realizes direct and rapid detection of chemical pollutants in propolis, and improves the defects of cumbersome sample pretreatment and long analysis time in the existing analysis technology.