Preparation method and product of organic-inorganic core-sheath structure composite biomaterial

Abstract

The invention discloses a preparation method of an organic-inorganic core sheath structure compound biological material and the product. The method particularly comprises the following steps: immersing a dopamine activated polypropylene mesh piece into an acellular matrix solution, then adding an MES buffer solution dissolved with EDC and NHS, and conducting light resistant reaction to obtain the organic-inorganic core sheath structure compound biological material, wherein the acellular matrix solution is an MES buffer solution containing acellular matrix. The preparation method is simple, needs no special equipment and easy for scale production, and the prepared organic-inorganic core sheath structure compound biological material not only has the mechanical property of polypropylene material, but also has the good tissue compatibility of the acellular matrix, has no obvious inflammatory reaction after being implanted, and is expected to be developed and applied to the fields of regeneration medicine and the like.

Description

technical field [0001] The invention belongs to the field of materials, and in particular relates to a preparation method of an organic-inorganic core-sheath structure composite biomaterial, and also relates to a product prepared by the method. Background technique [0002] Female pelvic organ prolapse is a common disease with a domestic incidence of about 40% and increasing year by year. It has become a major gynecological problem that seriously affects the health and quality of life of middle-aged and elderly women. Polypropylene synthetic material is widely used clinically as a gynecological pelvic floor patch. Although the patch is effective, it has disadvantages such as poor compliance, strong tissue erosion, and high infection rate, and it is easy to cause related complications such as dyspareunia. In 2014, the preparation method of pelvic bottom patch composite biomaterial and its products (patent number: ZL201210153430.8) authorized by the State Intellectual Property...

AI Technical Summary

Problems solved by technology

Polypropylene synthetic material is widely used clinically as a gynecological pelvic floor patch. Although the patch is effective, it has disadvantages such as poor compliance, strong tissue erosion, and high infection rate, and it is easy to cause related complications such as dyspareunia

In 2014, the preparation method of pelvic floor patch composite biomaterials and its products (patent number: ZL201210153430.8) authorized by the State Intellectual Property Office announced a method of using ultra-high pressure to composite natural materials on the surface of synthetic materials. A method, but this method requires the use of special equipment, complex operation, high cost, which limits large-scale production and use

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