PH-stimulus responsive nano-container and preparation method thereof

A nano-container and stimuli-response technology, applied in the field of material science, can solve the problems of increased toxicity, unfavorable excretion, and long residence time, and achieve the effects of reducing reaction steps, comprehensive and effective protection, and simple preparation methods

Inactive Publication Date: 2015-10-28
NANJING UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The controlled release of drugs from the carrier can ensure relatively stable treatment. After the drug is released, generally large-sized carrier materials cannot be decomposed. The volume is too large, and it stays in the blood for a long time, which is not conducive to excretion and increases toxicity.

Method used

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  • PH-stimulus responsive nano-container and preparation method thereof
  • PH-stimulus responsive nano-container and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1. Add 10 mg of 1-hexyl-3-methyl-imidazolium chloride to 75 ml of ethanol, and disperse it uniformly with ultrasound.

[0023] Add 5ml of ammonia water to the solution to form an alkaline environment, stir vigorously with a mechanical stirrer, slowly add 160ul of TEOS (tetramethylsilane) dropwise at 25°C for hydrolysis, and react at room temperature for 24h. After the reaction was completed, centrifugation was performed to collect the solid, washed three times with ethanol, and vacuum-dried at 60° C. to obtain the drug-carrying molecule.

[0024] In order to study the release effect of the nano-container under neutral and acidic conditions, the present invention carried out the following experiments: the release curve of the nano-container was detected at 210 nm by ultraviolet spectroscopy: 4 mg of drug-loaded molecules were accurately weighed, the solid was placed in the dialysis membrane, The dialysis membrane with product is then placed in a cuvette with a sealed top...

Embodiment 2

[0026] 1. Add 10 mg of 1-hexyl-3-methyl-imidazolium chloride to 75 ml of ethanol, and disperse it uniformly with ultrasound.

[0027] Add 5ml of ammonia water to the solution to form an alkaline environment, stir vigorously with a mechanical stirrer, slowly add 480ul of TEOS (tetramethylsilane) dropwise at 25°C for hydrolysis, and react at room temperature for 24h. After the reaction was completed, centrifugation was performed to collect the solid, washed three times with ethanol, and vacuum-dried at 60° C. to obtain the drug-carrying molecule.

[0028] In order to study the release effect of the nano-container under neutral and acidic conditions, the present invention carried out the following experiments: the release curve of the nano-container was detected at 210 nm by ultraviolet spectroscopy: 4 mg of drug-loaded molecules were accurately weighed, the solid was placed in the dialysis membrane, The dialysis membrane with product is then placed in a cuvette with a sealed top...

Embodiment 3

[0030] 1. Add 30 mg of 1-hexyl-3-methyl-imidazolium chloride to 75 ml of ethanol, and disperse it uniformly with ultrasound.

[0031] Add 5ml of ammonia water to the solution to form an alkaline environment, stir vigorously with a mechanical stirrer, slowly add 480ul of TEOS (tetramethylsilane) dropwise at 25°C for hydrolysis, and react at room temperature for 24h. After the reaction was completed, centrifugation was performed to collect the solid, washed three times with ethanol, and vacuum-dried at 60° C. to obtain the drug-carrying molecule.

[0032] In order to study the release effect of the nano-container under neutral and acidic conditions, the present invention carried out the following experiments: the release curve of the nano-container was detected at 210 nm by ultraviolet spectroscopy: 4 mg of drug-loaded molecules were accurately weighed, the solid was placed in the dialysis membrane, The dialysis membrane with product is then placed in a cuvette with a sealed top...

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Abstract

The invention discloses a pH-stimulus responsive nano-container and a preparation method thereof. The preparation method includes: subjecting imidazoline to ultrasonic dispersion in ethanol; adding ammonia water to adjust the pH value, adding TEOS dropwise slowly at room temperature and carrying out vigorous stirring reaction; and at the end of the reaction, conducting extraction and vacuum drying, thus obtaining the pH-stimulus responsive nano-container. Compared with other nano-containers, the pH-stimulus responsive nano-container provided by the invention is more adaptive to the environment and has high sensitivity, and at the same time of internal molecule release, the carrier decomposes, so that the nano-container can have wider application, and the preparation method is simple.

Description

technical field [0001] The invention belongs to the field of material science, in particular to a preparation method of a pH-stimulus-responsive nano-container. Background technique [0002] In the field of coatings, anti-corrosion coatings can hinder the corrosion of metal surfaces. Most anti-corrosion coatings are organic compounds containing oxygen, nitrogen, sulfur, phosphorus and aromatic compounds, which can form a film on the metal surface. However, these anti-corrosion coatings have certain toxicity and are prone to toxic effects on the human body. This coating also cannot adapt to changes in the environment and is not selective for a specific environment. [0003] In the field of biomedicine, the ideal drug-coated nanoparticles in medicine can be effectively taken up by cells, released in a controlled manner, and safely discharged from the organism. Improve the ability of cells to take up drugs, and if the surface of the carrier is hydrophilic, it is convenient fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K9/14A61K31/4164A61K47/54
Inventor 傅佳骏冯晶王明东丁晨迪刘梦阳
Owner NANJING UNIV OF SCI & TECH
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