Jintangning capsule quality detection method

A quality inspection method, the technology of Jintangning, is applied in the direction of measuring devices, instruments, scientific instruments, etc. It can solve the problems of unstable ingredient types and contents, inability to systematically and comprehensively reflect the internal quality of Jintangning capsules, and achieve evaluation Consistency, good reproducibility, fast operation effect

Active Publication Date: 2015-10-28
ZHANGZHOU PIEN TZE HUANG PHARM
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Problems solved by technology

However, because the quality of traditional Chinese medicinal materials is affected by many aspects such as the place of origin, climate, season, etc., the type and content of the ingredients contained are often unstable. For

Method used

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  • Jintangning capsule quality detection method
  • Jintangning capsule quality detection method
  • Jintangning capsule quality detection method

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Embodiment

[0040] A quality detection method for Jintangning capsules, comprising steps as follows:

[0041] 1. Preparation of the control characteristic map of Jintangning Capsules.

[0042] (1) Preparation of reference substance solution:

[0043] Take about 5 mg of picrolinic acid reference substance, accurately weigh it, put it in a 25ml measuring bottle, add water to dilute to the mark, and shake well; accurately measure 1ml, put 10ml in a test tube, add 1ml of water, add 0.8wt% of 2,4 - 2ml of dinitrofluorophenylacetonitrile solution and 2ml of 0.5mol / L sodium bicarbonate solution, placed in a water bath at 60°C for 1 hour, removed and allowed to cool, transferred to a 10ml measuring flask, and mixed with 0.2mol / L phosphate buffer (pH 7 .0) Wash the solvent for several times, put the lotion into a measuring bottle, add the above-mentioned phosphate buffer solution to dilute to the mark, shake well, and you get it.

[0044] (2) preparation of need testing solution

[0045]Take 0....

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Abstract

The present invention relates to a Jintangning capsule quality detection method, wherein a high performance liquid chromatography method is used to prepare the control characteristic map of the Jintangning capsule and the characteristic map of the Jintangning capsule to be tested, the mobile phase comprises acetonitrile, dimethylformamide and 0.025 mol/L sodium acetate according to a volume ratio of 24:0.5:76, the detection wavelength is 390 nm, the flow rate is 0.8 ml/min, and the similarity comparison is performed on the characteristic map of the Jintangning capsule and the control characteristic map of the Jintangning capsule, and the qualified standard is that the similarity is greater than 0.90. According to the present invention, the control characteristic map prepared by the method can completely reflect the quality information of the Jintangning capsule so as to effectively control the inherent quality of the Jintangning capsule; the established method has characteristics of good stability, good precision and good reproducibility; and the traditional Chinese medicine chromatography fingerprint similarity evaluation system software specified by the Chinese Pharmacopoeia Commission is used, such that the operation is convenient and the result is objective and accurate.

Description

technical field [0001] The invention relates to a quality detection method for traditional Chinese medicine capsules, in particular to a quality detection method for the characteristic spectrum of Jintangning capsules. Background technique [0002] The composition of traditional Chinese medicine is complex, and the effective part is often not a single component, and a single content determination index cannot fully reflect and control the quality of the preparation. Therefore, the fingerprint technology of traditional Chinese medicine came into being. [0003] Traditional Chinese medicine fingerprint technology originates from fingerprint identification, and uses modern information technology and quality analysis methods to comprehensively reflect the types and quantities of chemical components contained in traditional Chinese medicine. For Chinese medicinal materials, fingerprints can be used to identify the authenticity and judge the quality; for Chinese patent medicines, ...

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Application Information

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IPC IPC(8): G01N30/88G01N30/06
Inventor 陈纪鹏于娟吴丽璇
Owner ZHANGZHOU PIEN TZE HUANG PHARM
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