57results about How to "Control internal quality" patented technology

The invention relates to a HPLC (high-performance liquid chromatography) detection method capable of simultaneously detecting contents of six amino acids in a donkey-hide glue blood-supplementing preparation. The method comprises the following steps: providing a donkey-hide glue blood-supplementing preparation sample; providing an amino acid standard sample; respectively adding the donkey-hide glue blood-supplementing preparation sample and the amino acid standard sample into phenylisothiocyanate-acetonitrile solution; uniformly mixing and standing, and respectively adding n-hexane; uniformlymixing and standing once again, respectively extracting lower-layer solutions, and filtering to obtain a derivatized donkey-hide glue blood-supplementing preparation sample solution and a derivatizedamino acid standard sample solution; sucking the derivatized donkey-hide glue blood-supplementing preparation sample solution and the derivatized amino acid standard sample solution, and injecting into a liquid chromatograph to perform amino acid detection. According to the invention, the contents of six major amino acids in the donkey-hide glue blood-supplementing preparation are detected by adopting reversed-phase high-performance liquid-phase, the sample treatment method is simple, the detection method has good specificity, repeatability and accuracy, and the internal quality of donkey-hide glue blood-supplementing granules can be well controlled.

The invention relates to an extract of a single Chinese medicament, in particular to a glaucescent fissistigma root saponin extract and a preparation method thereof, a pharmaceutical composition, anti-tumor application thereof and the like.

The invention discloses a method for measuring the content of amino acid in a black-bone chicken milk increasing preparation. The method comprises the following steps: subjecting a black-bone chicken milk increasing preparation to a protein hydrolysis treatment; and then using an amino acid analyzer to analyze the hydrolysate so as to measure the amino acid content. In the conventional standards, the protein content can be only represented by total nitrogen content, the provided method can overcome the shortage, moreover, the method can precisely measure contents of 17 amino acids in the preparation, has the advantages of simple pretreatment, strong specificity, good repeatability, and high precision, can well control the quality of the black-bone chicken milk increasing preparation, and improves the safety and effectiveness of the preparation.

The invention provides a detection method of a traditional Chinese medicinal composition for treating waist and knee pains and sciatica. Raw materials of the traditional Chinese medicinal composition comprise Rhizoma Cibotii, Fructus Rosae Laevigatae, Caulis Spatholobi, Philippine flemingia root, Kadsura coccinea, Millettia specisoa Champ, Ligustri Lucidi Fructus, Chinese Taxillus Twig, semen cuscutae, Rhizoma Corydalis, Zanthoxylum nitidum, Boswellia carteri and myrrh. The detection method comprises the following steps: detecting the content of (2'S)-Kadsura longepedunculata lignin J in the Kadsura coccinea through high performance liquid chromatography; and detecting the content of specnuezhenide in the Ligustri Lucidi Fructus through the high performance liquid chromatography, and detecting the Kadsura coccinea, the Rhizoma Cibotii and the Chinese Taxillus Twig through thin layer chromatography. The invention also concretely discloses conditions and concrete operating steps of all above detection technologies. The detection method allows five raw materials to be qualitatively and quantitatively detected, and the quantity of the detected raw materials is 1/3 of the total quantity of the raw materials, so the quality of medicines is effectively guaranteed, and medical demands are met.

The lead-free, Li₂O-free, CuO-free and preferably arsenic-free optical glass is suitable for applications in the fields of imaging, projection, telecommunications, optical communication technology and/or laser technology, and has a refractive index n_d of 1.55≦n_d≦1.60, an Abbe number V_d of 54≦V_d≦63 and a transformation temperature Tg≦500° C. This optical glass has good production and processing properties and crystallization stability, and, at the same time, advantageously does not contain PbO and As₂O₃. These glasses contain, in percent by weight based on oxide content: P₂0₅, 43-56; ZnQ, 21-36; Al₂O₃, 0-6; Na₂O, 0-16; K₂O, 0-8; ΣM₂O ≦16; MgO, 0-5; CaO, 0-5; BaO, 3-14; B₂O₃, 0-8; La₂O₃, 0-7. In addition, it may also contain standard refining agents.

The invention relates to a method for identifying a glossy privet fruit medicinal material or a derivative. The method comprises the following steps: extracting the glossy privet fruit medicinal material or the derivative to obtain a glossy privet fruit iridoid glycoside characteristic extract containing an active ingredient group; performing IGD (Inverted Gated Decoupling) nuclear magnetic resonance carbon spectrum fingerprint detection on the glossy privet fruit iridoid glycoside characteristic extract, and obtaining characteristic peak intensities of a plurality of active ingredients in the glossy privet fruit iridoid glycoside characteristic extract according to the fingerprint; measuring the characteristic peak intensity of a standard reference object corresponding to each active ingredient in the same manner; measuring the absolute content of the standard reference object through a quantitative analysis method; calculating the content of each active ingredient and the content of the active ingredient group in the glossy privet fruit medicinal material or a derivative by using the ratio of the characteristic peak intensities and the absolute content of the standard reference object. According to the method, the glossy privet fruit iridoid glycoside compounds contained in the glossy privet fruit and the ratio of the compounds can be reflected so as to achieve the aims of variety identification and quality determination of the glossy privet fruit medicinal material.

The disclosed quality control method for longipeduncle kadsura alcohol extract comprises: with dry extract weight as base, determining total lignans content not less than 5.6% with ultraviolet spectrophotometry, or the ester content not less than 0.7% by HPLC, or lignans not less than 1.0% by HPLC. This invention has well control effect.

The invention provides an HPLC (high-performance liquid chromatography) fingerprint spectrum measurement method for a standard Yunujian decoction, and belongs to the technical field of traditional Chinese medicine. The HPLC fingerprint spectrum measurement method includes (1), preparing a sample solution for test; (2), preparing a mixed reference substance solution; (4), accurately sucking the sample solution for test and the mixed reference substance solution, and injecting the solutions into a high-performance liquid chromatograph for measurement to acquire liquid chromatograms of the samplesolution for test and the mixed reference substance solution; (5), matching data of the liquid chromatograms of the sample solution for test and the mixed reference substance solution by traditionalChinese medicinal chromatography fingerprint spectrum similarity evaluation system software made by Chinese Pharmacopeia Commission to acquire a standard fingerprint spectrum. The HPLC fingerprint spectrum measurement method for the standard Yunujian decoction has the advantages that quality of standard Yunujian particles is controlled effectively, curative effect of the medicine is guaranteed, and the classic prescription is enabled to be under standard quality control.

The present invention discloses quality control method for vitality source preparation. The quality control method includes the identification of ophiopogon, ginsenoside, schisandra and astragalus in the vitality source preparation; the limit inspection of aconitine; and the measurement of ginsenoside content. The identification, the inspection and the measurement may be adopted alone or in combination in the quality control. The present invention makes it possible to raise the quality of vitality source preparation so as to ensure the stable and reliable curative effect of vitality source preparation and reduce adverse reaction.

The invention discloses a method for simultaneously detecting the contents of four components of a traditional Chinese medicine for treating children cough. The traditional Chinese medicine for treating children cough is prepared from burdock, mulberry leaves, bulbus fritillariae cirrhosae, mint, radix isatidis, schizonepeta spike, fructus aurantii, radix peucedani, aster and liquorice, the four components are liquiritin, naringin, neohesperidin and arctiin, and the method comprises the following steps: extracting a sample to be detected with an extraction solvent, and detecting with a high performance liquid chromatograph. According to the method, the contents of the four substances can be detected at the same time, the adopted chromatographic conditions are good in separation effect, short in peak appearance time, good in detection result reproducibility and high in accuracy, and the quality of the traditional Chinese medicine is more controllable.

A method for measuring the content of schizandrin A in the Chinese medicine prepared from the alcohol extract of schisandra fruit includes such steps as experiment of chromatographic condition and system adaptivity, preparing the solution of reference, preparing the solution of specimen, and measuring.

The present invention relates to a Jintangning capsule quality detection method, wherein a high performance liquid chromatography method is used to prepare the control characteristic map of the Jintangning capsule and the characteristic map of the Jintangning capsule to be tested, the mobile phase comprises acetonitrile, dimethylformamide and 0.025 mol/L sodium acetate according to a volume ratio of 24:0.5:76, the detection wavelength is 390 nm, the flow rate is 0.8 ml/min, and the similarity comparison is performed on the characteristic map of the Jintangning capsule and the control characteristic map of the Jintangning capsule, and the qualified standard is that the similarity is greater than 0.90. According to the present invention, the control characteristic map prepared by the method can completely reflect the quality information of the Jintangning capsule so as to effectively control the inherent quality of the Jintangning capsule; the established method has characteristics of good stability, good precision and good reproducibility; and the traditional Chinese medicine chromatography fingerprint similarity evaluation system software specified by the Chinese Pharmacopoeia Commission is used, such that the operation is convenient and the result is objective and accurate.

The invention discloses a quality control method of intestine astringe antidiarrheic preparation. The intestine astringe antidiarrheic preparation consists of 7 to 18 parts by weight of featherleaf rodgersflower extract, 700 to 800 parts by weight of bentonite and auxiliary materials with appropriate quantity. The quality control method of the intestine astringe antidiarrheic preparation comprises the following steps of utilizing high-efficient liquid-phase chromatography to determine content of bergenin in the preparation; determining content of aluminum oxide in the intestine astringe antidiarrheic preparation; and determining content of silicon dioxide in the intestine astringe antidiarrheic preparation. The quality control method is characterized in that on the basis of the traditional standard, the main active component bergenin is quantitatively detected, and main active components such as aluminum oxide and silicon dioxide in the preparation are quantitatively detected. The method is operable, simple, feasible and capable of effectively controlling the quality of the intestine astringe antidiarrheic preparation.

The invention relates to a construction method for fermentation tank assembled by precast slabs. The construction method comprises the following steps that: a base plate of the fermentation tank is poured; first precast slabs are circumferentially arranged on a base plate of the fermentation tank in a positioned way at intervals; each second precast slab is arranged between every two neighbouring first precast slabs in a positioning mode, so as to make each first precast slab and each second precast slab assemble into a closed tank wall together; each first precast slab is connected with each second precast slab through steel strands to make the first precast slab and the second precast slab connected as a whole by stretching the steel strands; a seam between each first precast slabs and each second precast slab is sealed, and the seams of the base plate of the fermentation tank and the first precast slab and the second precast slab are sealed; the steel strands are stretched for a second time, and finally the tank top and the relevant fermentation equipment are arranged. According to the construction method for fermentation tank assembled by precast slabs, the closed wall of the fermentation tank is assembled by multiple first precast slabs and multiple second precast slabs, therefore, the construction speed and working efficiency of the fermentation tank are increased.

The invention provides a processing method of high-quality bombyx mori linnaeus. The processing method comprises the following steps of a, taking fresh bombyx mori linnaeus which is dead due to infection of beauveria assiana (Bals.)Vuillant, wherein the infection mode involves artificial breeding infection or natural infection; b, harvesting, wherein the bombyx mori linnaeus is harvested within 24-48 hours after 80% of the bombyx mori linnaeus is dead; c, conducting pretreatment, wherein bombyx mori linnaeus bodies are spread flat, and subjected to ventilation and dehydration treatment for atleast 6 hours for ossification; d, conducting processing, wherein two-section-type circular drying is adopted for scale production, hot-air drying is conducted for 2 hour at 80 DEG C, and after dehydration, low-temperature drying is conducted at 60 DEG C; drying in the sun or drying in the shade is adopted for production site preliminary processing. The processing method is high in operability, the cost is reduced, the method is suitable for scale production and processing of the bombyx mori linnaeus, and the quality is high.

The invention provides a UPLC characteristic chromatogram construction method of endothelium corneum gigeriae galli decoction pieces, fried endothelium corneum gigeriae galli decoction pieces, vinegar endothelium corneum gigeriae galli decoction pieces, standard decoction of the endothelium corneum gigeriae galli decoction pieces and formula granules of the endothelium corneum gigeriae galli decoction Determining the liquid to be detected by adopting a high performance liquid chromatography to obtain UPLC characteristic chromatograms of the endothelium corneum gigeriae galli decoction pieces, the fried endothelium corneum gigeriae galli decoction pieces, the vinegar endothelium corneum gigeriae Chromatographic conditions of the high performance liquid chromatography are as follows: a chromatographic column is a C18 column; a mobile phase A is a methanol solution, a mobile phase B is a 0.02% acetic acid aqueous solution, and gradient elution is carried out. According to the method, the UPLC characteristic chromatogram for distinguishing the endothelium corneum gigeriae galli decoction pieces, the fried endothelium corneum gigeriae galli decoction pieces, the vinegar endothelium corneum gigeriae galli decoction pieces, the standard decoction and the formula granules of the endothelium corneum gigeriae galli decoction pieces, the fried endothelium corneum gigeriae galli decoction pieces and the vinegar endothelium corneum gigeriae galli decoction pieces is established,

The invention discloses a method for simultaneously detecting contents of five components of a traditional Chinese medicine for treating infantile enuresis. The traditional Chinese medicine for treating infantile enuresis is prepared from six traditional Chinese medicinal materials including ephedra, cinnamon, alpinia oxyphylla, ginkgo, semen cuscutae and endothelium corneum gigeriae galli, the five components include ephedrine hydrochloride, cinnamaldehyde, cinnamic acid, quercetin and ginkgolide C. The detection method comprises the steps that the traditional Chinese medicine is extracted through an extraction solvent and then detected through a high performance liquid chromatograph. Compared with the methods in the prior art, the method has the advantages of high detection sensitivity,high speed, simplicity in operation and the like, the detection efficiency and the detection accuracy are greatly improved, and the internal quality of the traditional Chinese medicine can be more comprehensively controlled.

The invention provides a fingerprint spectrum determination method and a quality control method for the reference substance of Guyin decoction. The invention confirms 12 common characteristic peaks in the process of establishing the fingerprint spectrum of the Guyin decoction substance reference, solves the problems of difficulty in separating the fingerprint characteristic peaks and the interference of impurity peaks, and ensures the chemical composition stability and use safety of the substance reference , which provides an important reference for the quality control of the subsequent preparations, effectively controls the quality of the Guyin decoction substance benchmark, and enables the classic prescriptions to get more formal quality control.

The invention discloses a detection method of traditional Chinese medicine ingredients in Chenxianglubailu tablets. Under the same chromatographic condition, quality control is performed on liquiritin, narirutin and hesperidin in a Chenxianglubailu preparation simultaneously, and thin-layer qualitative discrimination is performed on rhizoma acori graminei. The product quality can be effectively controlled, the method is simple and convenient to operate, high in accuracy and high in specificity, and the working efficiency of product inspection is improved.