Detection method of traditional Chinese medicine ingredients in Chenxianglubailu tablets

A detection method, the technology of Bailu Tablets, is applied in the direction of measuring devices, material separation, and analysis of materials. The effect of promoting intestinal peristalsis

Inactive Publication Date: 2018-08-03
贵州省科晖制药有限公司
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Problems solved by technology

[0004] Regarding the quality control of traditional Chinese medicine ingredients in Chenxianglu Bailu Tablets, the published literature is only about the TLC identification method of four Chinese medicinal materials such as Chuanmuxiang and the content control method of a single component. There is no method for qualitative identification of Shichangpu medicinal materials. There is no method for controlling liquiritin, rutin naringin or simultaneous control of liquiritin, rutin naringin and hesperidin by high performance liquid chromatography

Method used

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  • Detection method of traditional Chinese medicine ingredients in Chenxianglubailu tablets
  • Detection method of traditional Chinese medicine ingredients in Chenxianglubailu tablets
  • Detection method of traditional Chinese medicine ingredients in Chenxianglubailu tablets

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Effect test

experiment example

[0028] Experimental example: content determination of liquiritin, rutin naringin and hesperidin

[0029] (1) Selection of detection wavelength

[0030] Referring to the relevant literature and using high-performance liquid chromatography, an appropriate amount of mixed reference substance was taken for injection, and a diode array detector was used to scan in the wavelength range of 190-800nm. The results showed that the maximum absorption wavelength of liquiritin was 277nm, and the maximum absorption wavelength of rutin naringin was 283nm, the maximum absorption wavelength of hesperidin is 284nm, choose a wavelength that can detect the above three active ingredients at the same time, and finally determine the detection method for the simultaneous determination of liquiritin, rutin naringin and hesperidin in Chenxianglu Bailu Tablets The wavelength is 277nm.

[0031] (2) Selection of mobile phase

[0032] Mobile phase 1: methanol-0.5% acetic acid (32:68);

[0033] Mobile ph...

Embodiment

[0096] A detection method of traditional Chinese medicine components in Chenxianglu Bailu Tablets, comprising:

[0097](1) Chromatographic conditions and system suitability experiment: the chromatographic column is Phenomenex Gemini C18 (250mm×4.6mm, 5μm); with acetonitrile-0.2% acetic acid (19:81) as the mobile phase; the detection wavelength is 277nm; the column temperature is 30 ℃; the flow rate is 1ml / min; the number of theoretical plates should not be less than 5000 based on the peak of liquiritin.

[0098] (2) Preparation of reference solution: Accurately weigh the appropriate amount of reference substances of liquiritin, rutin naringin, and hesperidin, add methanol to make a solution containing 20 μg of liquiritin, 20 μg of rutin and 100 μg of hesperidin per 1 ml , that is;

[0099] (3) Preparation of the test solution: Grind Chenxianglu Bailu Tablets finely, take about 0.5g, accurately weigh it, put it in a stoppered conical flask, add 50ml of methanol precisely, weig...

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Abstract

The invention discloses a detection method of traditional Chinese medicine ingredients in Chenxianglubailu tablets. Under the same chromatographic condition, quality control is performed on liquiritin, narirutin and hesperidin in a Chenxianglubailu preparation simultaneously, and thin-layer qualitative discrimination is performed on rhizoma acori graminei. The product quality can be effectively controlled, the method is simple and convenient to operate, high in accuracy and high in specificity, and the working efficiency of product inspection is improved.

Description

technical field [0001] The invention belongs to the technical field of quality control of Chinese and Western medicine compound preparations, and in particular relates to a detection method for Chinese medicine components in Chenxianglu Bailu Tablets. Background technique [0002] Chenxianglu Bailu Tablets is a compound preparation of Chinese and Western medicine, the prescription is licorice 100g, tangerine peel 100g, Chuanmuxiang 38.2g, Shichangpu 9.2g, rhubarb 8.3g, bismuth subnitrate 110g, sodium bicarbonate 67g, magnesium carbonate 33.7g, oxidized Magnesium 33.7g. It has the effects of invigorating the stomach, regulating qi and relieving pain, and is used for hyperacidity and epigastric pain caused by chronic gastritis. Dried tangerine peel is the main traditional Chinese medicine of this preparation. It is warm in nature, pungent in taste and bitter in taste. In addition, it is compatible with basic drugs such as bismuth subnitrate, which is more conducive to neut...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/90
CPCG01N30/02G01N30/90
Inventor 冯发进霍昕陆宽李凤崔伟杨迺嘉
Owner 贵州省科晖制药有限公司
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