Liquid chromatography-tandem mass spectrometry method for detection of specific total migration of nine ultraviolet absorbers

Abstract

The present invention provides a liquid chromatography-tandem mass spectrometry method for detection of specific total migration of nine ultraviolet absorbers. The method is as below: soaking a sample to be measured in a food simulant, cooling to room temperature and mixing well; diluting the water-based food simulant with ethanol by 1:10, filtering by a hydrophilic PTFE filter and introducing the sample; extracting the olive oil with acetonitrile n-heptane, and filtering the lower clear liquid with a hydrophilic PTFE filter and introducing the sample; Conducting gradient elution and separation by a C8 column; and running under negative multiple reaction monitoring mode by using a mass spectrometry with electro-spray ionization source. The method has good chromatographic separation and linear relationship, high recovery and accuracy, meets the limit requirements on specific total migration of the 9 ultraviolet absorbers in EU regulations (EU) NO 10/2011, and has been applied to actual detection of samples.

Description

technical field [0001] The invention belongs to the field of chemical detection, and relates to a detection method for the specific migration of 9 kinds of harmful ultraviolet absorbers in food contact materials, in particular to a high performance liquid chromatography tandem mass spectrometry (HPLC-MS / MS) method for detecting plastic food contact Method for Specific Migration of 9 UV Absorbers in Materials. technical background [0002] Plastic food contact materials often need to add functional additives such as ultraviolet absorbers (UV) and antioxidants to prolong the service life of related products. However, during the use of the product, these added UVs will also migrate into the food, directly endangering human health. The (EU) NO 10 / 2011 regulation issued by the European Union in 2011 limits the specific migration amount (SML) or specific total migration amount [SML(T)] of various UVs. [0003] At present, the detection of ultraviolet absorbers at home and abroad...

AI Technical Summary

Problems solved by technology

The reported detection methods for UV absorbers in food simulants are all HPLC methods. Due to the differences in the types and numbers of UV absorbers detected at the same time, the existing detection methods cannot be used for the second schedule of the (EU) NO 10 / 2011 regulation. Specific total migration of 9 kinds of UV absorbers in

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