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Purposes of piperlongumine used for preparing medicine preventing cerebral arterial thrombosis

A technology for ischemic stroke and smilamide, which is applied in the field of medicine to achieve the effects of less toxic and side effects and high clinical application value

Active Publication Date: 2015-12-02
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] There is no literature report on the use of smilaxamide in the prevention and treatment of ischemic stroke

Method used

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  • Purposes of piperlongumine used for preparing medicine preventing cerebral arterial thrombosis
  • Purposes of piperlongumine used for preparing medicine preventing cerebral arterial thrombosis
  • Purposes of piperlongumine used for preparing medicine preventing cerebral arterial thrombosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: The animal experiment that smilaxamide is used for the treatment of ischemic stroke

[0025] The pharmacological experiment of making focal cerebral ischemia model by mouse suture method is a commonly used animal experiment to verify that drugs have the effect of preventing and treating ischemic stroke, so it is used to verify the protective effect of smilaxamide on cerebral ischemia in experimental animals.

[0026] According to the new drug review requirements, the ICR mouse cerebral ischemia-reperfusion model was prepared by the suture method (for details, please refer to the pharmacology, pharmacology and toxicology part of the "Guiding Principles for Preclinical Research of New Western Drugs", the Ministry of Health of the People's Republic of China. Administration Bureau, 1993:73; "Pharmacological Experimental Methodology" second edition, People's Health Publishing House, 1982:830, 1113), except for the sham operation group, the rest of the groups wer...

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PUM

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Abstract

The invention relates to the medical technology field, and provides purposes of piperlongumine used for preparing a medicine preventing cerebral arterial thrombosis. Through pharmacological test of a mouse focal cerebral ischemia model, the facts are discovered that piperlongumine can improve behavior symptoms caused by mouse cerebral ischemia reperfusion injury obviously, the cerebral infarction size is reduced, and encephaledema degree of a mouse with cerebral ischemia is lowered. Thus piperlongumine can be used for preparing a medicine preventing cerebral arterial thrombosis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a new application of smilax amide, that is, the application of smilax amide in the preparation of drugs for preventing and treating ischemic stroke. Background technique [0002] Cardiovascular and cerebrovascular diseases are common and frequently-occurring diseases that seriously endanger human health, among which stroke is the primary cause of human disability. [0003] Ischemic stroke, also known as cerebral ischemia, is the most common type of stroke. It is a central nervous system disease characterized by a decrease in cerebral blood flow as the main pathological feature. It has high morbidity, disability, and mortality. Human health poses a serious threat, especially the health and quality of life of the elderly, which has become a huge burden on the health resources of the global society. At present, there are few effective drugs used in the treatment of ischemic cerebr...

Claims

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Application Information

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IPC IPC(8): A61K31/4412A61P9/10
Inventor 谢和辉李铁军董晓慧王利苹姜玉孙昕彭程
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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