Application of ieodoglucomides B to prepare monoamine oxidase (MAO) inhibitor
A technology of monoamine oxidase and inhibitor, which is applied in the application field of preparing monoamine oxidase MAO inhibitor, and achieves the effect of strong inhibitory activity and outstanding substantive characteristics
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Embodiment 1
[0011] Example 1: Preparation of IeodoglucomidesB tablet of the compound involved in the present invention:
[0012] Take 5 grams of compound Ieodoglucomides B and add 195 grams of dextrin, mix well, and prepare 1000 tablets with a conventional tablet machine.
Embodiment 2
[0013] Example 2: Preparation of the compound IeodoglucomidesB capsule of the present invention:
[0014] Take 5 grams of compound Ieodoglucomides B and add 195 grams of starch, mix them, and encapsulate them to make 1000 tablets.
[0015] The following pharmacodynamic experiments will further illustrate its drug activity.
[0016] The compound IeodoglucomidesB is used to detect the inhibitory activity of MAO-A and MAO-B by fluorescent probe method,
[0017] The described method follows the following steps:
[0018] Dissolve the sample to be tested in DMSO to prepare a series of samples with a concentration gradient. Take 4ul of MAO (10mg / ml), boric acid buffer (PH=8.4), 50ulBSA (50mg / ml), add the sample solution to be tested, mix well, react in a water bath at 30~38℃ for 3h, then add probe 7- (3-Aminopropoxy) coumarin 2ul (50mmol / ml), the final concentration of inhibitor is 0~10-2mmol / l, and the mixture is reacted in a water bath at 30±5℃ for 12h, using a fully functional fluorescenc...
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