Spleen-strengthening blood stasis-removing Chinese herbal compound composition and application thereof
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A composition and compound technology, which is applied in the field of traditional Chinese medicine compound composition for invigorating the spleen and removing blood stasis, can solve the problems of increased incidence and seriousness of thrombosis events, adverse events, etc., and achieve good safety and definite clinical curative effect
Inactive Publication Date: 2016-03-23
JIANGSU PROVINCIAL HOSPITAL OF TCM
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In recent years abroad, a number of large-scale clinical studies have confirmed that long-term use of selective COX-2 inhibitors may cause serious thrombotic events
[0006] In 2006, Bertaqnolli et al. found that when studying the preventive effect of low-dose celecoxib (200mg, 2 times/d) and high-dose (400mg, 2 times/d) on sporadic colorectal adenomatous polyps, although celecoxib can Significantly reduced the recurrence rate of colorectal adenoma, but the incidence of adverse events
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[0018] Example 1 Preparation of water decoction of Chinese medicine compound for strengthening the spleen and removing blood stasis.
[0019] Composition of Jianpi Huayu Recipe: Lu Codonopsis 15g, Stir-fried Baizhu 10g, Poria 15g, Chinese Yam 15g, Raw Astragalus 20g, Simmered Wood Fragrant 10g, Tangerine Peel 5g, Curcuma 10g, Ishinomori 30g, Roasted Black Plum 10g, Raw Hawthorn 15g, Roasted licorice 3g.
[0020] The above formula is made into a water decoction to prevent adenoma recurrence.
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[0021] Example 2 Preparation of water decoction of Chinese medicine compound for strengthening the spleen and removing blood stasis.
[0022] The composition of Jianpi Huayu Recipe: Lu Codonopsis 10g, Fried Atractylodes 15g, Poria 10g, Chinese Yam 20g, Raw Astragalus 15g, Simmered Wood Fragrant 15g, Tangerine Peel 3g, Curcuma 15g, Ishikawa 25g, Roasted Black Plum 15g, Raw Hawthorn 10g and Roasted licorice 5g.
[0023] The above formula is made into a water decoction to prevent adenoma recurrence.
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[0024] Example 3 Preparation of a Chinese herbal compound decoction for strengthening the spleen and removing blood stasis.
[0025] The composition of Jianpi Huayu Recipe: Ludangshen 20g, Fried Atractylodes 8g, Poria 20g, Chinese Yam 10g, Raw Amaranth 25g, Simmered Wood Fragrant 8g, Tangerine Peel 8g, Curcuma 8g, Ishinomori 35g, Zhiwu Mei 8g, Raw Hawthorn 15g and Roasted licorice 2g.
[0026] The above formula is made into a water decoction to prevent adenoma recurrence.
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Abstract
The invention discloses a spleen-strengthening blood stasis-removing Chinese herbal compound composition which comprises, by weight parts, 10-20 parts of codonopsis pilosula Nnannf, 8-15 parts of stir-fried atractylodes, 10-20 parts of poria cocos, 10-20 parts of rhiizoma dioscoreae, 15-25 parts of raw coix seed, 8-15 parts of roasted radix aucklandiae, 3-8 parts of tangerine peel, 8-15 parts of curcuma zedoaria, 25-35 parts of salvia chinensis, 8-15 parts of roasted dark plum fruit, 10-15 parts of raw hawthorn and 2-5 parts of prepared liquorice root. The invention further discloses application of the spleen-strengthening blood stasis-removing Chinese herbal compound composition to preparation of medicines for preventing colorectal adenoma relapse. The spleen-strengthening blood stasis-removing Chinese herbal compound composition fills the blank of orally administrated medicines for clinically preventing adenoma relapse. The clinical effect is precise, the safety is good, the composition is proved according to normative clinical and trial study, and the action mechanism study is performed from the molecular level.
Description
technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a Chinese medicine compound composition for invigorating the spleen and removing blood stasis and its application. Background technique [0002] Colorectal adenoma is recognized as the precancerous lesion of colorectal cancer, and more than 80% of colorectal cancers evolve from adenoma. After adenoma resection, the incidence of colorectal cancer can be reduced by 76% to 90%, but it is easy to relapse after adenoma resection, and the annual recurrence rate is 10% to 15%. Some patients even have new adenomas every year and need colonoscopy Lower resection. Every time adenoma is removed under colonoscopy, the patient not only has to endure the pain of colonoscopy and pay a relatively high fee, but also bears the risks of intestinal bleeding, perforation, infection and other treatment that may be caused by adenoma resection. Therefore, clinical I...
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