Spleen-strengthening blood stasis-removing Chinese herbal compound composition and application thereof

Abstract

The invention discloses a spleen-strengthening blood stasis-removing Chinese herbal compound composition which comprises, by weight parts, 10-20 parts of codonopsis pilosula Nnannf, 8-15 parts of stir-fried atractylodes, 10-20 parts of poria cocos, 10-20 parts of rhiizoma dioscoreae, 15-25 parts of raw coix seed, 8-15 parts of roasted radix aucklandiae, 3-8 parts of tangerine peel, 8-15 parts of curcuma zedoaria, 25-35 parts of salvia chinensis, 8-15 parts of roasted dark plum fruit, 10-15 parts of raw hawthorn and 2-5 parts of prepared liquorice root. The invention further discloses application of the spleen-strengthening blood stasis-removing Chinese herbal compound composition to preparation of medicines for preventing colorectal adenoma relapse. The spleen-strengthening blood stasis-removing Chinese herbal compound composition fills the blank of orally administrated medicines for clinically preventing adenoma relapse. The clinical effect is precise, the safety is good, the composition is proved according to normative clinical and trial study, and the action mechanism study is performed from the molecular level.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a Chinese medicine compound composition for invigorating the spleen and removing blood stasis and its application. Background technique [0002] Colorectal adenoma is recognized as the precancerous lesion of colorectal cancer, and more than 80% of colorectal cancers evolve from adenoma. After adenoma resection, the incidence of colorectal cancer can be reduced by 76% to 90%, but it is easy to relapse after adenoma resection, and the annual recurrence rate is 10% to 15%. Some patients even have new adenomas every year and need colonoscopy Lower resection. Every time adenoma is removed under colonoscopy, the patient not only has to endure the pain of colonoscopy and pay a relatively high fee, but also bears the risks of intestinal bleeding, perforation, infection and other treatment that may be caused by adenoma resection. Therefore, clinical I...

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Problems solved by technology

In recent years abroad, a number of large-scale clinical studies have confirmed that long-term use of selective COX-2 inhibitors may cause serious thrombotic events

[0006] In 2006, Bertaqnolli et al. found that when studying the preventive effect of low-dose celecoxib (200mg, 2 times / d) and high-dose (400mg, 2 times / d) on sporadic colorectal adenomatous polyps, although celecoxib can Significantly reduced the recurrence rate of colorectal adenoma, but the incidence of adverse events also increased with the dose increase

Previous studies on the prevention of recurrence of colorectal adenoma by traditional Chinese medicine mainly focused on enema treatment, but enema treatment has its limitations, and its therapeutic effect on the right colon is almost zero. Therefore, the first choice for preventing recurrence of adenoma should be oral preparations. At present, there are still no oral drugs clinically used to prevent the recurrence of adenoma at home and abroad.

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