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A kind of pharmaceutical composition containing ginkgolide B and phosphodiesterase inhibitor and its preparation method and application

A technology of phosphodiesterase and ginkgolide, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of small side effects, high cost, and high price, and reduce the amount of use , the effect of a clear mechanism of action

Active Publication Date: 2019-03-15
CHENGDU BAIYU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Ginkgolide B is an active ingredient extracted from the natural medicine Ginkgo biloba. It has few side effects and strong activity. It is the strongest platelet activating factor antagonist found so far, but the price is high, and the cost of clinical use is too high

Method used

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  • A kind of pharmaceutical composition containing ginkgolide B and phosphodiesterase inhibitor and its preparation method and application
  • A kind of pharmaceutical composition containing ginkgolide B and phosphodiesterase inhibitor and its preparation method and application
  • A kind of pharmaceutical composition containing ginkgolide B and phosphodiesterase inhibitor and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Ginkgolide B10 parts

[0040] Cilostazol 50 parts

[0041] Pharmaceutically acceptable conventional excipients

[0042] After the above-mentioned raw materials are mixed, a pharmaceutically acceptable conventional auxiliary material is added to prepare a pill according to a conventional process.

Embodiment 2

[0044] Ginkgolide B10 parts

[0045] Cilostazol 100 parts

[0046] Pharmaceutically acceptable conventional excipients

[0047] After mixing the above-mentioned raw materials, add conventional pharmaceutically acceptable auxiliary materials to prepare capsules or soft capsules according to conventional processes.

Embodiment 3

[0049] Ginkgolide B1 part

[0050] Cilostazol 10 parts

[0051] Pharmaceutically acceptable conventional excipients

[0052] After the above raw materials are mixed, add pharmaceutically acceptable conventional adjuvants and prepare tablets according to conventional techniques.

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PUM

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Abstract

The invention provides a pharmaceutical composition containing ginkgolide B. The pharmaceutical composition comprises the ginkgolide B and phosphodiesterase inhibitor. The invention further provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition has the advantages that the ginkgolide B and the phosphodiesterase inhibitor are combined to achieve a synergic effect, and the pharmaceutical composition is excellent in platelet aggregation inhibiting effect, low in side effect and promising in clinical application prospect; the pharmaceutical composition is novel in prescription, simple in component, clear in action mechanism, evident in curative effect, less prone to tolerance generating and capable of achieving large-scale industrial production.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing ginkgolide B. Background technique [0002] Both cilostazol and sildenafil are phosphodiesterase inhibitors, which can inhibit platelet aggregation and have antithrombotic effect. [0003] Cilostazol, Chinese name: 6-[4-(1-cyclohexyl-1H-pentazol-5-yl)butoxy]-3[1],4-dihydro-2(1H)-quinolone , molecular formula: C 2 0H 2 7N 5 o 2 Molecular weight: 369.4607 Molecular structure: [0004] [0005] Cilostazol can inhibit platelet aggregation, has antithrombotic effect, and is used to treat local diseases such as chronic arterial occlusive ulcer, pain and cold sensation. The main adverse reactions are headache, dizziness and palpitation, etc. Some patients may have high blood pressure, followed by abdominal distension, nausea, vomiting, stomach discomfort, abdominal pain and other gastrointestinal symptoms. Abnormal uric acid value, occasional allergic reactions, including rash, itching...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4709A61K31/519A61K45/00A61P7/02A61K31/365
Inventor 孙毅
Owner CHENGDU BAIYU PHARMA CO LTD
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