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Pharmaceutical composition for treating thrombotic diseases and application thereof

A technology for thrombotic diseases and compositions, applied in drug combinations, blood diseases, cardiovascular system diseases, etc., can solve problems such as bleeding, and achieve significant effects and low toxic and side effects.

Inactive Publication Date: 2016-07-13
张雪燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because platelets play an important role in the process of blood coagulation and thrombus formation, antiplatelet drugs are currently one of the commonly used drugs for clinical treatment of thrombotic diseases. The main clinical drugs used to treat thrombotic diseases mainly include Aspirin, clopidogrel, abciximab, etc., but because they all have different degrees of risk of bleeding, aspirin and clopidogrel also have the problem of "drug resistance" and cause gastrointestinal reactions, so to a certain extent restrictions on the use of these drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] The preparation of embodiment 1 Chinese medicine granule

[0013] Weigh 2.0kg of cucumber vines, 1.1kg of scorpion grass, 1.1kg of apocynum, 1.8kg of three-headed rushes, 0.6kg of polygala, 0.6kg of evergreen, 2.5kg of corn silk and 2.5kg of Sophora japonica, combine them, add water to decoct twice, Add water for the first time to 12 times the weight of the medicinal materials, decoct for 2 hours, add water for the second time to 10 times the weight of the medicinal materials, decoct for 1.5 hours, combine the decoctions, and concentrate under reduced pressure at 0.08MPa and 70℃ to 70℃ The relative density is 1.15, add 95% (v / v) ethanol to make the alcohol content reach 75% (v / v), stir, let it stand overnight, filter, and concentrate the filtrate under reduced pressure at 0.08MPa and 65°C to thicken Paste, placed in a stainless steel pan, vacuum dried (below 70°C) into a dry paste, crushed, added 4 times the amount of sucrose powder, dry granulated, packaged, 15g per pa...

Embodiment 2

[0014] The preparation of embodiment 2 Chinese medicine oral liquid

[0015] Weigh 2.2kg of cucumber vines, 1.0kg of weeds, 1.0kg of apocynum, 2.0kg of three-headed rushes, 0.8kg of polygala, 0.6kg of evergreens, 2.6kg of corn silk and 3.0kg of Sophora japonica, mix them, and crush them into large particles; Add water to the above-mentioned granular medicinal materials to cover the medicinal surface 2cm, soak for 1-1.2h, remove the medicinal materials, put them in a multi-functional extraction tank, add water and decoct twice, add 12 times the amount of water for the first time, decoct for 2 hours, take Decoction, filter, add 10 times the amount of water for the second time, decoct for 1.5h, take two decoctions and combine, filter, concentrate to a concentrated solution with a relative density of 1.25 at 90°C; put the concentrated solution in Refrigerate at 2-5°C for 24 hours, add 0.3% diatomite filter aid to the refrigerated liquid, filter, and then concentrate the filtrate t...

Embodiment 3

[0016] The preparation of embodiment 3 Chinese medicine oral liquid

[0017] Weigh 2.9kg of cucumber vines, 1.2kg of scorpion grass, 1.2kg of apocynum, 1.5kg of three-headed rushes, 0.8kg of polygala, 0.5kg of evergreen, 3.0kg of corn silk and 3.0kg of Sophora japonica, combine them, add water to decoct twice, Add water for the first time to 12 times the weight of the medicinal materials, decoct for 2 hours, add water for the second time to 10 times the weight of the medicinal materials, decoct for 1.5 hours, combine the decoctions, and concentrate under reduced pressure at 0.08MPa and 70℃ to 70℃ The relative density is 1.20, add 95% (v / v) ethanol to make the alcohol content reach 75% (v / v), stir, stand overnight, filter, and concentrate the filtrate to 65% under reduced pressure at 0.08MPa and 65°C The relative density at ℃ is 1.15. Add water and sucrose to prepare oral liquid.

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating thrombotic diseases and the application thereof.The pharmaceutical composition is prepared from, by weight, 17-22 parts of cucumber stem, 9-12 parts of herba siegesbeckiae, 8-13 parts of apocynum venetum, 15-20 parts of juncus triceps, 5-8 parts of polygala root, 5-8 parts of rohdea japonica, 21-30 parts of corn stigma and 21-30 parts of flos sophorae.The pharmaceutical composition has a remarkable anticoagulation effect, can treat thrombotic diseases and is especially suitable for treating thromboangitis obliterans.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating thrombotic diseases and its application. Background technique [0002] Thrombotic disease is a type of disease that seriously endangers human health and life, including acute coronary syndrome, ischemic cerebrovascular disease, thromboangiitis obliterans, thrombosis in diabetes, and thrombosis caused by acute tumors. rate, morbidity and mortality are high. Because platelets play an important role in the process of blood coagulation and thrombus formation, antiplatelet drugs are currently one of the commonly used drugs for clinical treatment of thrombotic diseases. The main clinical drugs used to treat thrombotic diseases mainly include Aspirin, clopidogrel, abciximab, etc., but because they all have different degrees of risk of bleeding, aspirin and clopidogrel also have the problem of "drug resistance" and cause gastrointes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P9/14A61P7/02
CPCA61K36/42A61K36/24A61K36/28A61K36/489A61K36/69A61K36/88A61K36/896A61K36/899A61K2300/00
Inventor 张雪燕
Owner 张雪燕
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