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Use of alpha-crystallin b (CRYAB) in the assessment of heart failure

A heart failure and multipurpose technology, applied in the field of CRYAB measurement kits, can solve the problems of insufficient labeling and low survival rate

Inactive Publication Date: 2016-07-20
F HOFFMANN LA ROCHE & CO AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

5-year survival rate less than 30%
[0032] However, as in many other areas of diagnostics, a single marker is not enough

Method used

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  • Use of alpha-crystallin b (CRYAB) in the assessment of heart failure
  • Use of alpha-crystallin b (CRYAB) in the assessment of heart failure
  • Use of alpha-crystallin b (CRYAB) in the assessment of heart failure

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Embodiment Construction

[0041] In a first embodiment, the invention relates to a method of assessing heart failure in an individual comprising the steps of: a) measuring the concentration of the marker protein alpha-crystallin B (CRYAB) in a sample obtained from the individual; b) optionally, measuring the concentration of one or more other markers of heart failure in the sample; and c) by comparing the concentration determined in step (a) and optionally the concentration determined in step (b) with that determined in the control sample Established concentrations of this marker or these markers are compared to assess heart failure.

[0042] As used herein, each of the following terms has the meaning associated with it in this section.

[0043] The article "a" ("a" and "an") is used herein to refer to one or more than one (ie, at least one) of the grammatical object of an article. For example, "antibody" means one antibody or more than one antibody.

[0044] The expression "one or more" means 1 to 5...

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Abstract

The invention relates to a method for assessing heart failure in vitro comprising the steps of measuring in a sample the concentration of the marker CRYAB, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure selected from the group consisting of a natriuretic peptide marker, a cardiac troponin marker, and a marker of inflammation, and of assessing heart failure by comparing the concentration determined in for CRYAB and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of CRYAB as a marker protein in the assessment of heart failure, a marker combination comprising CRYAB and a kit for measuring CRYAB.

Description

field of invention [0001] The present invention relates to a method of assessing heart failure in an individual comprising the steps of: a) measuring the concentration of the marker protein alpha crystallin B (CRYAB) in a sample obtained from the individual; b) optionally measuring one or more The concentration of other markers of heart failure, and by comparing the concentration determined in step (a) and optionally the concentration determined in step (b) with the concentration of this or these markers as established in the control sample comparison to assess heart failure. Also disclosed are the use of alpha crystallin B (CRYAB) as a marker protein in the assessment of heart failure, a marker combination comprising CRYAB, and a kit for measuring CRYAB. Background of the invention [0002] Heart failure (HF) is an important and growing public health problem. Taking the United States as an example, there are approximately 5 million HF patients and more than 550,000 patien...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6887G01N2333/4712G01N2800/325G01N33/6893
Inventor U-H.温许斯-特伦G.黑斯D.布洛克H.许迪希A.埃米利A.格拉莫利尼P.刘D.麦克莱南S.阿拉布
Owner F HOFFMANN LA ROCHE & CO AG