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Preparation method of dexamethasone calcium phosphate hydrogel

A technology of dexamethasone calcium phosphate and dexamethasone sodium phosphate, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., and can solve the increase of pharmaceutical costs, the toxic and side effects of adjuvants, etc. problems, to achieve the effects of precise and controllable drug loading, simple preparation, and rapid gel formation

Inactive Publication Date: 2016-07-27
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This will not only increase the cost of pharmaceuticals, but also introduce adjuvant-related side effects

Method used

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  • Preparation method of dexamethasone calcium phosphate hydrogel

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Using double distilled water as a solution, prepare 1.5% dexamethasone calcium phosphate hydrogel at a temperature of 25°C:

[0015] Accurately weigh 3 mg of dexamethasone sodium phosphate and dissolve it in 1 ml of double distilled water, add an equal volume of calcium chloride aqueous solution with a concentration of 2 mg / ml, let stand at room temperature, and form dexamethasone calcium phosphate hydrogel after about 2 minutes.

Embodiment 2

[0017] Using double distilled water as a solution, prepare 2.5% dexamethasone calcium phosphate hydrogel at a temperature of 25°C:

[0018] Accurately weigh 5 mg of dexamethasone sodium phosphate and dissolve it in 1 ml of double distilled water, add an equal volume of calcium chloride aqueous solution with a concentration of 2 mg / ml, let stand at room temperature, and form dexamethasone calcium phosphate hydrogel after about 10 sce.

Embodiment 3

[0020] Using double distilled water as a solution, prepare 5% dexamethasone calcium phosphate hydrogel at a temperature of 25°C:

[0021] Accurately weigh 10 mg of dexamethasone sodium phosphate and dissolve it in 1 ml of double-distilled water, add an equal volume of calcium chloride aqueous solution with a concentration of 2 mg / ml, let stand at room temperature, and immediately form dexamethasone calcium phosphate hydrogel.

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Abstract

Provided is a preparation method of a dexamethasone calcium phosphate hydrogel. By mixing a dexamethasone sodium phosphate solution with a Ca<2+> containing aqueous solution, the dexamethasone sodium phosphate solution and the Ca<2+> containing aqueous solution can spontaneously form the dexamethasone calcium phosphate hydrogel in a self-assembly mode. The preparation method of the dexamethasone calcium phosphate hydrogel has the advantages of being simple in preparation, quick in hydrogel forming and accurate and controllable in drug loading capacity.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a preparation method of dexamethasone calcium phosphate hydrogel. Background technique [0002] As an anti-inflammatory and anti-allergic drug, dexamethasone is mainly used as emergency medicine for critical illness and treatment of various inflammations. It is a relatively safe steroid hormone drug. In current domestic hospitals, the drug penetration rate is nearly 100%. At present, many glucocorticoid drugs have been listed in the world, and they are mainly used clinically as anti-inflammatory, anti-allergic, anti-asthma, anti-psoriasis and anti-eczema drugs. However, long-term use of dexamethasone can cause many adverse reactions, such as weight gain, lower limb edema, avascular necrosis of the humerus or femoral head, hypokalemia syndrome, peptic ulcer or perforation, glaucoma, cataract, etc. Nowadays, with the increasingly widespread application of drugs and the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/573A61K47/04A61P29/00A61P37/08
CPCA61K9/06A61K31/573A61K47/02
Inventor 李星熠师帅何治芬陈浩
Owner WENZHOU MEDICAL UNIV
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