Alkaloid composition and application thereof

A composition and alkaloid technology, applied in the field of natural medicinal chemistry, can solve problems such as allergic reactions, large side effects of finasteride tablets, scalp desquamation of patients, etc., and achieve the effect of promoting hair follicle growth

Inactive Publication Date: 2016-08-17
ANHUI JIUFANG DRUG RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the side effects of finasteride tablets are relatively large: it is not suitable for women and children, and the adverse events of male patients are as follows: abnormal ejaculation, breast tenderness and swelling, allergic reactions (including rash, itching, urticaria and swelling of the lips) and testicular pain , and even impotence and loss of libido
Although minoxidil can have a good curative effect on androgenetic alopecia and alopecia areata, it also has many adverse reactions. The adverse reaction is hirsutism, and it can also cause irritation or allergic contact allergic reactions. Some patients may develop rashes. Symptoms of Itching and Scalp Scalp
[0005] At present, in the prior art, there is no drug that can effectively treat alopecia areata, seborrheic alopecia, and pityriasis alopecia without any side effects.

Method used

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  • Alkaloid composition and application thereof
  • Alkaloid composition and application thereof
  • Alkaloid composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Get the roots of the genus Phyllostachys chinensis and crush them, add 6 times the amount of ethanol to carry out countercurrent dynamic heating extraction, each time for 3 hours, collect the extract, filter, and concentrate the filtrate under reduced pressure to (temperature 70 ° C, vacuum number -0.08Npa ) per 1ml is equivalent to 5g of tuber, dissolved in hot water, acidified with hydrochloric acid, stirred, left to stand, filtered to obtain the filtrate, refrigerated to stand for 48 hours, filtered, added alkali to alkalize, stirred, left to stand, filtered to obtain the drug liquid;

[0044] The obtained medicinal liquid is filtered through a ceramic membrane filter for molecular interception, the pore size of the ceramic membrane filter is 0.2 μm, and the obtained filtrate is the fine filtrate;

[0045]Pass the fine filtrate through an ionic resin column, wash with water to remove impurities, then elute with 85% ethanol, collect the eluate, concentrate under reduc...

Embodiment 2

[0055] Extraction method: Take the roots of the plant of Fangjiaceae, Cervus chinensis, crush and add 8 times the amount of ethanol to carry out countercurrent dynamic heating extraction, each time for 2 hours, collect the extract, filter, and concentrate the filtrate under reduced pressure to (temperature 70 ° C, vacuum number - 0.08Npa) per 1ml is equivalent to 4g of raw medicinal materials, dissolve in hot water, add hydrochloric acid to acidify, stir, stand still, filter to obtain the filtrate, refrigerate and stand for 48 hours, filter, add alkali to alkalize, stir, stand still, filter passed liquid medicine;

[0056] The obtained medicinal liquid is filtered through a ceramic membrane filter for molecular interception, the pore size of the ceramic membrane filter is 0.1 μm, and the obtained filtrate is the fine filtrate;

[0057] Pass the fine filtrate through an ionic resin column, wash with water to remove impurities, then elute with 90% ethanol, collect the eluate, co...

Embodiment 3

[0065] Extraction method: Take the roots of the plant of Fangjiaceae Cervus chinensis, crush and add 5 times the amount of ethanol to carry out countercurrent dynamic heating extraction, each time for 4 hours, collect the extract, filter, and concentrate the filtrate under reduced pressure to (temperature 70 ° C, vacuum number - 0.08Npa) per 1ml is equivalent to 5g of tubers, dissolved in hot water, acidified with sulfuric acid, stirred, left to stand, filtered to obtain filtrate, refrigerated to stand for 48 hours, filtered, added alkali to alkalize, stirred, left to stand, filtered get liquid medicine;

[0066] The obtained medicinal liquid is filtered through a ceramic membrane filter for molecular interception, the pore size of the ceramic membrane filter is 0.3 μm, and the obtained filtrate is the fine filtrate;

[0067] Pass the fine filtrate through an ionic resin column, wash with water to remove impurities, then elute with ethanol, collect and elute

[0068] liquid, ...

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PUM

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Abstract

The present invention provides an alkaloid composition, which is characterized by comprising the following raw materials in weight ratio: 23-27% of Homoa romoline, 4-6% of berbamine, 50-52% of isotetrandrine, 3-5% of cycleanine, and 12-15% of cepharanthine. The invention also discloses the application of the alkaloid composition in preparing drugs for treating alopecia areata, alopecia seborrhoeica and chaff sex baldness. The alkaloid composition obviously promotes the hair follicle growth. Meanwhile, the alkaloid composition obviously promotes the proliferation of hair papilla cells cultured in vitro.

Description

technical field [0001] The invention relates to the field of natural medicinal chemistry, in particular to an alkaloid composition and its application. Background technique [0002] As early as 2000, the World Health Organization stated in a report published that hair loss (baldness) is becoming a global problem. According to the statistics of national authoritative health institutions, among the adult population in my country, there are more than 300 million people with thin and soft hair, withered and yellow hair, split ends and hair loss, among which there are about 162.5 million people with hair loss. According to the latest survey data on hair health, 60% of men experience hair loss before the age of 25, and more than 80% (83.9%) of men experience hair loss before the age of 30. The hair loss population is showing a younger trend. [0003] At present, hair loss patients in China generally have not established the awareness of "hair loss is a disease". In fact, when ha...

Claims

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Application Information

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IPC IPC(8): A61K31/4748A61K36/59A61P17/14
CPCA61K31/4748A61K36/59A61K2300/00
Inventor 牛海军邵旭李晓亮许亮李光辉
Owner ANHUI JIUFANG DRUG RES INST CO LTD
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