Implication solid-phase logic gate and its construction method based on bsa/3-mpa-gold nanocluster-polyelectrolyte

Abstract

The invention discloses an implication type solid-phase logic gate based on BSA (bull serum albumin) / 3-MPA (mercaptopropionic acid)-gold nanocluster-polyelectrolyte and a construction method of the implication type solid-phase logic gate. On the basis of the phenomenon that H+ can inhibit fluorescence quenching of Fe2+ to a BSA / 3-MPA-gold nanocluster-polyelectrolyte solid-phase compound in an acetic acid buffer solution with the pH value of 4.6, the Fe2+ and the H+ are taken as input signals, the gold nanocluster-polyelectrolyte solid-phase compound serves as a signal converter, and an implication type solid-phase logic gate system is created. The logic gate system has the advantages of simplicity and convenience in operation (without any modifying and marking processes), high transferability, capability of being reset, diversification in signal reading and the like, and has good application prospect in the fields of clinical diagnosis, chemical sensing, environment monitoring and the like.

Description

technical field [0001] The invention relates to an IMPLICATION solid-phase logic gate based on BSA / 3-MPA-gold nano cluster-polyelectrolyte complex and a construction method thereof, belonging to the field of nanotechnology. Background technique [0002] In the past few decades, chemical Boolean logic gates have attracted extensive attention and have been applied in many fields such as clinical diagnosis, chemical sensing, and environmental monitoring. At present, different types of logic gates, such as AND, OR, NOR, NAND, IMPLICATION, and INHIBIT, can be constructed by using different materials (such as nucleic acids, enzymes, organic molecules, and nanomaterials). However, most of the logic operation systems have the following disadvantages: (1) involve complex modification or labeling process, and the cost is high; (2) they are not resettable; (3) they are poor in portability and difficult to attach to solid surfaces; (4) ) cannot process multiple input signals at the sam...

AI Technical Summary

Problems solved by technology

However, most of the logic operation systems have the following disadvantages: (1) involve complex modification or labeling process, and the cost is high; (2) they are not resettable; (3) they are poor in portability and difficult to attach to solid surfaces; (4) ) cannot handle multiple input signals at the same time and the integration between logic gates is very difficult

Although many fluorescent dyes have been reported to perform logic operations, the problems of high cost, poor photostability, prone to autoxidation, and high toxicity limit their further applications.

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