Application of S-ademetionine in preparation of fetus protection medicines, dysmenorrhea treatment medicines and uterus health products

An adenosylmethionine and drug technology, applied in the field of medicine, can solve problems such as side effects, and achieve the effects of less side effects, reducing dysmenorrhea and premature birth, and inhibiting contractions

Active Publication Date: 2016-09-07
仙鹤生物科技(杭州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The analysis shows that these anti-tocotropic drugs will have certain side effects on both mother and fetus

Method used

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  • Application of S-ademetionine in preparation of fetus protection medicines, dysmenorrhea treatment medicines and uterus health products
  • Application of S-ademetionine in preparation of fetus protection medicines, dysmenorrhea treatment medicines and uterus health products
  • Application of S-ademetionine in preparation of fetus protection medicines, dysmenorrhea treatment medicines and uterus health products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Mix S-adenosylmethionine with PBS (pH7.4) to configure enough medicines for treating dysmenorrhea in three parts with different concentrations, wherein the concentration of S-adenosylmethionine solution is 0.1mmol / L, 0.3mmol / L and 1.0mmol / L respectively. mmol / L.

[0050] Repeat the above steps, mix S-adenosylmethionine with PBS (pH7.4), and configure enough three parts of different concentrations of tocolytic drugs, wherein the concentration of S-adenosylmethionine solution is 0.1mmol / L, 0.3mmol / L, respectively. L and 1.0mmol / L.

[0051] Contraction test of isolated uterine smooth muscle in ICR mice

[0052] ①Preparation of uterine smooth muscle strips from non-pregnant ICR mice

[0053] The non-pregnant ICR mice were injected with 0.5mg diethylstilbestrol (DES) 24h-48h in advance, the ICR mice were killed by cervical dislocation, the uteri were dissected, and the uterus was divided into 4-6 uterine muscle strips in the Roth's solution. The length of the muscle strip...

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Abstract

The invention relates to application of S-ademetionine in preparation of fetus protection medicines, dysmenorrhea treatment medicines and uterus health products, and belongs to the field of medicines. The invention also provides application of S-ademetionine with a pharmaceutically acceptable carrier in preparation of fetus protection medicines and dysmenorrhea treatment medicines. The carrier can be nontoxic filler, a stabilizing agent, a diluting agent, adjuvant or other preparation auxiliaries, and is safe and effective to fetus protection and dysmenorrhea treatment. The invention further provides application of the S-ademetionine in preparation of uterus health products. After the health products are taken by females, the occurrence probability of dysmenorrhea, abortion and premature delivery can be effectively reduced.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to the application of S-adenosylmethionine in the preparation of tocolytic drugs, drugs for treating dysmenorrhea and uterine health care products. Background technique [0002] According to the report of the World Health Organization (WHO) in 2013, about 15 million premature babies are born in the world every year, that is, more than one in every 10 babies comes to this world prematurely, and this number is still rising; at the same time, Every year, more than 1 million premature babies die from premature birth complications, and many surviving children also face lifelong disabilities in vision, hearing and other aspects. [0003] There are currently seven main categories of drugs for the treatment of premature labor: β-adrenergic receptor agonists, oxytocin receptor antagonists, calcium channel blockers, NO donors such as nitroglycerin, prostaglandin synthase inhibitors, magnesium ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7076A61K47/04A61K9/08A61P15/06A61P15/00
CPCA61K9/0019A61K9/08A61K9/19A61K31/7076A61K47/02
Inventor 汤慧芳
Owner 仙鹤生物科技(杭州)有限公司
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