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A compound codonopsis total saponins immune polysaccharide nanoemulsion composition and preparation method thereof

A technology of immune polysaccharide and total saponins, applied in the field of medicine, can solve the problems of less research on immune regulation and differences in solubility, and achieve the effects of improving drug bioavailability, low viscosity and improving drug solubility

Active Publication Date: 2019-11-19
YUNCHENG UNIVERISTY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although Codonopsis saponins and Poria cocos polysaccharides have a good immune-enhancing effect, their disadvantages are: Codonopsis total saponins and Poria cocos polysaccharides contain a variety of monomers, and the solubility of the monomers may have certain differences. How to improve them Solubility is an issue that needs to be addressed
In the study of immune regulation of traditional Chinese medicine, most studies are on single medicine or its monomer components, while there are few studies on the immune regulation of Chinese medicine compound.

Method used

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  • A compound codonopsis total saponins immune polysaccharide nanoemulsion composition and preparation method thereof
  • A compound codonopsis total saponins immune polysaccharide nanoemulsion composition and preparation method thereof
  • A compound codonopsis total saponins immune polysaccharide nanoemulsion composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1) Weighing: 5.50g of Codonopsis total saponins, 5.50g of Poria cocos polysaccharide, 5.50g of licorice polysaccharide, 32.00g of polyoxyethylene ether (40) hydrogenated castor oil, 3.50g of polyethylene glycol 400, 8.00g of isopropyl myristate , distilled water 40.00g, spare;

[0035] 2) At 25°C, add the co-surfactant polyethylene glycol 400 to the surfactant polyoxyethylene ether (40) hydrogenated castor oil to obtain a mixed surfactant; Active agent, then add the oily phase isopropyl myristate, stir and mix, and the result is the mixed oily phase;

[0036] 3) Dissolve licorice polysaccharide in distilled water at 25°C, stir to dissolve, and the obtained is the water phase;

[0037] 4) At 25°C, slowly drop the water phase into the mixed oil phase, continuously stir while dropping, and then pass it through a nanoemulsifier to obtain the compound codonopsis total saponins immune polysaccharide nanoemulsion composition.

Embodiment 2

[0039]

[0040]

[0041] The total mass ratio of the above-mentioned raw materials is 100%, and its specific preparation method is the same as in Example 1.

Embodiment 3

[0043]

[0044] The total mass ratio of the above-mentioned raw materials is 100%, and its specific preparation method is the same as in Example 1.

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Abstract

The invention relates to a compound radix codonopsis total saponins and immunopolysaccharides nano emulsion composition and a preparation method thereof. The nano emulsion composition provided by the invention is an oil in water type nano emulsion, has particle sizes between 1nm and 100nm, and is prepared from the following ingredients of three traditional Chinese medicinal active ingredients (radix codonopsis total saponins, pachyman and a radix glycyrrhizae polysaccharide), a surfactant, a cosurfactant, an oil phase and distilled water. The preparation method of the nano emulsion provided by the invention is simple and feasible; a device is easy to control; the product quality is easy to control; the particle size of a liquid drop is small; the solubility and the stability of a medicine can be improved; the proliferation activity of a splenic lymphocyte of an immunocompromised mouse can be improved. The nano emulsion composition provided by the invention can be used for obviously improving the immunoregulatory activity of the three traditional Chinese medicinal active ingredients, and has the potential of developing an immunopotentiator, so as to promote the development and the utilization of a traditional Chinese medicinal resource and an active ingredient thereof.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a compound codonopsis total saponins immune polysaccharide nanoemulsion composition, in particular to a nanoemulsion immune enhancer containing total codonopsis saponins, licorice polysaccharide and poria cocos polysaccharide as active components of traditional Chinese medicine. Background technique [0002] Traditional Chinese medicine has the advantages of rich resources, few side effects, and no drug residues, and has become a hot spot in the research of immune enhancers. Codonopsis Codonopsis is a traditional tonic, which can enhance physical fitness, improve human immunity, and has functions such as anti-aging, anti-oxidation, anti-hypoxia, anti-fatigue, and anti-tumor. Codonopsis total saponins, as one of its main active ingredients, have good immunoregulatory activity: it can act on natural killer cells and macrophages to enhance the body's non-specific immunity; it can enhance the a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K36/484A61P37/04A61K31/715
CPCA61K9/1075A61K31/715A61K36/076A61K36/344A61K36/484A61K47/44A61K2300/00
Inventor 曹发昊王艳萍刘中华
Owner YUNCHENG UNIVERISTY
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