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Medicine carrier of slow-release medicine

一种药物、载体的技术，应用在药物输送、医药配方、高分子化合物非有效成分等方向，能够解决未端释药不完全等问题

Inactive Publication Date: 2016-11-09
钟术光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] One of the main purposes of the present invention is to provide a drug carrier with improved performance for sustained release. Problems such as "drug release first and then slow" or "incomplete drug release at the end" shown in the test were alleviated or resolved

Method used

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  • Medicine carrier of slow-release medicine
  • Medicine carrier of slow-release medicine
  • Medicine carrier of slow-release medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0236]

[0237] Note: a1, the main performance parameters of this particle are shown in Table 1;

[0238] b1, the preparation method of the sodium polyacrylate particles: see the preparation method of the acidic (or alkaline) water-insoluble and swellable polymer (particle) in the comparative example below.

Embodiment 2

[0240]

[0241] Note: a2, the main performance parameters of this particle are shown in Table 1;

[0242] b2, the preparation method of the polylysine citrate particles: see the preparation method of the acidic (or alkaline) water-insoluble and swellable polymer (particle) in the comparative example below.

Embodiment 3

[0244]

[0245] Note: a3, the main performance parameters of this particle are shown in Table 1;

[0246] [b3, the preparation method of the sodium polyacrylate particles: see the preparation method of the acidic (or alkaline) water-insoluble and swellable polymer (particle) in the comparative example below.

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PUM

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Abstract

The invention discloses a medicine carrier of a slow-release medicine. The medicine carrier contains a fatty additive, additive particles, an acidic or alkaline polymer, alkaline or acidic matter, water-soluble surfactant and a medicine, wherein the in-vivo melting point and the in-vitro melting point of the fatty additive are higher than 37 DEG C; the additive particles are water-soluble, low in viscosity and free of irritation; the acidic or alkaline polymer has the water swelling property and water insolubility. The medicine carrier has a better medicine release characteristic, a better salt poisoning prevention effect and better medicine release uniformity, can better relieve or solve the terminus release problem, and has lower mucosa irritation and better biocompatibility, and medication safety problems like medicine burst release or dosage dumping are not likely to happen.

Description

technical field [0001] The invention relates to a medicine carrier for sustained release of medicine. More specifically, the present invention relates to a drug carrier for sustained-release drug with improved properties, the drug carrier includes aliphatic additives with in vivo and in vitro melting points greater than 37°C, water-soluble low-viscosity additive particles, water Swellable water-insoluble acidic (or basic) polymer, basic (or basic) excipient (material), water-soluble surfactant and drug. technical background [0002] Sustained-release preparations such as sustained-release suppositories, especially those with oily materials as the main sustained-release material, often exhibit the so-called "terminal release" problem, that is, the release of the drug is fast in the early stage, gradually slows down in the middle stage, and slows down in the later stage. Often, a part of the drug remains in the matrix within the specified (or expected) action time, and the ex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K38/14A61K47/34A61K47/12A61K47/14A61K47/10
CPCA61K9/0002A61K9/02A61K9/1635A61K9/1641A61K9/2013A61K9/2018A61K9/2031A61K9/2077A61K38/14A61K47/06A61K47/14A61K47/183A61K47/26A61K47/34A61K47/36A61K47/40A61K47/42A61K47/44
Inventor 钟术光
Owner 钟术光
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