Oral slow-release tablet of antihypertensive drug and preparation method thereof

A slow-release tablet and sustained-release preparation technology, applied in the field of pharmaceutical preparations, can solve the problems of adverse reactions of patients, irritation and side effects of the digestive system and respiratory system, and achieve the goal of reducing adverse reactions, alleviating adverse reactions, and preventing the formation of thrombus Effect

Inactive Publication Date: 2017-03-22
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since hypertension is a chronic disease, patients generally need long-term medication to control it. Some patients may experience adverse reactions to varying degrees during long-term use of exist

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] An oral slow-release tablet of an antihypertensive drug, comprising an inner pill and a slow-release layer wrapped on the outside of the pill;

[0026] The pill comprises the following components, and the following components are parts by weight,

[0027] 3 parts of captopril, 1 part of aspirin, 30 parts of skullcap, 10 parts of herb, 6 parts of Mingdangshen, 13 parts of Panax notoginseng, 3 to 5 parts of woody fragrance, 8 parts of nard pine, 6 parts of Parts of Solanum nigrum, 55 parts of forming agent;

[0028] Also includes 7 servings of Sophora japonica.

[0029] The slow-release layer includes the following components, and the following components are parts by weight,

[0030] 100 parts of sustained release agent, 60 parts of filler, 15 parts of antioxidant, 20 parts of stabilizer.

[0031] The molding agent includes the following components,

[0032] 40wt% sodium alginate, 20wt% sodium stearoyl lactylate, and the balance being gelatin.

[0033] The sustained...

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PUM

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Abstract

The invention discloses an oral slow-release tablet of an antihypertensive drug. The oral slow-release tablet is prepared from an internal pill and a slow-release layer wrapping the outer side of the pill, wherein the pill is prepared from the following components in parts by weight: 3 to 5 parts of captopril, 1 to 2 parts of aspirin, 25 to 30 parts of radix scutellariae, 10 to 12 parts of rhizoma atractylodis, 5 to 7 parts of radix changii, 10 to 15 parts of radix notoginseng, 3 to 5 parts of radix aucklandiae, 5 to 10 parts of rhizoma nardostachyos, 5 to 8 parts of herba solani nigri and 40 to 60 parts of forming agent; the slow-release layer is prepared from the following components in parts by weight: 100 to 120 parts of slow-release agent, 50 to 60 parts of filling agent, 10 to 15 parts of antioxidant and 20 to 25 parts of stabilizing agent. The invention further discloses a preparation method of the oral slow-release tablet of the antihypertensive drug. The oral slow-release tablet of the antihypertensive drug can overcome the defects in the prior art and reduce the risk that patients have untoward effects.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an oral slow-release tablet of an antihypertensive drug and a preparation method thereof. Background technique [0002] Hypertension is one of the most common cardiovascular diseases. Hypertension is the main cause of various diseases such as arteriosclerosis and myocardial infarction. Inspired by the development of medical technology, various antihypertensive drugs have been continuously developed. However, since hypertension is a chronic disease, patients generally need to take medicine for a long time to control it. Some patients may experience adverse reactions to varying degrees during the long-term use of existing antihypertensive drugs. For example, the commonly used antihypertensive drug captopril, some patients will experience irritation and side effects of the digestive system and respiratory system after use. Contents of the invention [0003] T...

Claims

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Application Information

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IPC IPC(8): A61K36/84A61K9/22A61K47/14A61K47/26A61P9/12A61K31/616A61K31/401
CPCA61K36/84A61K9/0002A61K9/2013A61K9/2018A61K31/401A61K31/616A61K36/23A61K36/258A61K36/284A61K36/285A61K36/539A61K36/81A61K2300/00
Inventor 何远知
Owner 何远知
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