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Application of cornulin as a target in the preparation of drugs for preventing and treating psoriasis

A technology of cornulin and psoriasis, applied in the field of biomedicine, can solve the problems of unclear etiology, satisfied patients with curative effect, easy recurrence of the disease, etc., and achieves good safety and good safety effect.

Active Publication Date: 2019-12-27
XI AN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] There are many treatments for psoriasis, including corticosteroids, retinoic acids, vitamin D3 derivatives, calcineurin inhibitors and other drugs, but because the etiology of the disease is unclear, The curative effect of many current treatment methods does not satisfy the patients, and the disease is prone to relapse. Due to the adverse drug reactions or drug prices in the treatment of psoriasis, the clinical use of these drugs is limited.

Method used

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  • Application of cornulin as a target in the preparation of drugs for preventing and treating psoriasis
  • Application of cornulin as a target in the preparation of drugs for preventing and treating psoriasis
  • Application of cornulin as a target in the preparation of drugs for preventing and treating psoriasis

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Embodiment Construction

[0027] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0028] The present invention finds that the expression of cornulin increases in psoriasis patient skin lesions and imiquimod mouse skin lesions, and application of M5 (IL-17A, IL-22, IL-1a, OSM and TNF-a mixture) stimulates HaCaT and After HEKa cells simulate the psoriasis cell level, the expression of cornulin increases; these suggest that cornulin is positively correlated with the development of psoriasis, and the present invention will be further described in detail below.

[0029] 1) Establishment of imiquimod mouse model

[0030] Purchase 6-7 week BALB / c mice, after 2% chloral hydrate anesthesia, shave the back hair about 2*2cm in size, apply imiquimod cream 62.5mg, once a day, apply different concentrations (0.5ng / ml , 1ng / ml and 2ng / ml) of CRNN antibody (catalog number: 11799-1-AP) 40...

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Abstract

The invention discloses an application of Cornulin as a target in preparation of a drug for preventing and treating psoriasis. Cornulin is taken as the drug target on the gene level and / or the protein level for the drug. Cornulin is positively correlated with development of psoriasis, when a Cornulin antibody with proper concentration is used for treating an imiquimod mouse model of psoriasis, scales and skin lesion thickness can be improved, and AKT signals can be inhibited to inhibit development of psoriasis and inhibit skin lesion for returning to normal; compared with other psoriasis treating drugs, and the Cornulin antibody has the advantages that the intervention target is clearer, that is, AKT signal related molecular pathways in inflammatory pathways for psoriasis incidence are targeted.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to the application of Cornulin in the preparation and prevention of psoriasis. Background technique [0002] Psoriasis is an inflammatory, immune-mediated chronic skin disease characterized by hyperplasia and abnormal differentiation of keratinocytes and infiltration of inflammatory cells. The clinical feature of psoriasis is silvery-white scales overlying erythema, and the long-term disease development seriously affects the quality of life of patients. The histopathology of typical psoriasis is: epidermal hypokeratosis, often accompanied by hyperkeratosis; granular layer disappears, spinous layer is hypertrophic, epidermal process is extended, and the lower end is widened, which can coincide with the adjacent epidermal process, and dermal papilla is extended, The spinous layer above it becomes thinner. Basal cells may have mild sponging, or even vacuolation or edema degeneration...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/395A61K31/7105A61K48/00A61P17/06C12Q1/6883G01N33/68G01N33/558
CPCA61K31/7105A61K39/395A61K2039/505C12Q1/686C12Q1/6883C12Q2531/113C12Q2545/114C12Q2561/113C12Q2563/107G01N33/558G01N33/6881G01N2333/46G01N2333/4704G01N2800/20
Inventor 郑焱李昌吉杨佩雯
Owner XI AN JIAOTONG UNIV
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