A kind of preparation of silver-gold alloy nanosphere shell based on vaprotide acetate

A technology of silver-gold alloy and vaprotide is applied in the field of preparation of nanomaterials, which can solve the problems affecting the performance of nanomaterials, uneven particle distribution, large particle size differences, etc., and achieves high biocompatibility, simple structure, and high uniform effect

Active Publication Date: 2018-12-28
YANSHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in previous preparation studies, due to the special morphology and special bond interactions of the alloy nanosphere shell, its morphology is not easy to control, the particle distribution on the surface of the spherical shell is uneven, the particle size varies greatly, and the product purity is also lower, which greatly affects the properties of nanomaterials
Moreover, these preparation methods generally have the disadvantages of polluting the environment, complicated process, and high cost.

Method used

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  • A kind of preparation of silver-gold alloy nanosphere shell based on vaprotide acetate
  • A kind of preparation of silver-gold alloy nanosphere shell based on vaprotide acetate
  • A kind of preparation of silver-gold alloy nanosphere shell based on vaprotide acetate

Examples

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Comparison scheme
Effect test

Embodiment 1

[0023] Get 0.91 mg of vapreotide acetate (Wuhan Dongkangyuan Technology Co., Ltd.), dissolve it in 1 mL of hydrochloric acid solution with pH 5.0, and prepare a vapreotide acetate solution with a concentration of 0.8 mM, place the vapreotide acetate solution in 65°C metal bath for 20 minutes; mix 500 μL of vapreotide acetate solution after the metal bath with 500 μL of 3.0 mM silver nitrate solution (Tianjin Chemical Reagent Factory) and put it into a constant temperature oscillator in a water bath. The control speed is 122 rpm and the temperature is 24°C Incubate under conditions for 24 hours; add 30 μL of 60 mM sodium borohydride (produced by Beijing Zhongsheng Huateng Technology Co., Ltd.) dropwise for reduction, 30 μL / drop, at a temperature of 24 ° C, and react for 16 min until the solution slowly changes from transparent to gray-black; finally Put the above-prepared solution in a boiling water bath at 100°C for 10 minutes, add 200 μL of 0.3 mM gold trichloride solution, an...

Embodiment 2

[0026] Take 1.02 mg of vapreotide acetate (Wuhan Dongkangyuan Technology Co., Ltd.), dissolve it in 1 mL of hydrochloric acid solution with pH 6.0, and prepare a vapreotide acetate solution with a concentration of 0.9 mM, and place the vapreotide acetate solution in 66°C metal bath for 22 minutes; mix 500 μL of vapreotide acetate solution after the metal bath with 500 μL of 6.0 mM silver nitrate solution (Tianjin Chemical Reagent Factory) and put it into a water bath constant temperature oscillator, control the speed at 124 rpm, and the temperature at 24°C Incubate under these conditions for 25 hours; add 60 μL of 80 mM sodium borohydride (produced by Beijing Zhongsheng Huateng Technology Co., Ltd.) dropwise for reduction, at a rate of 3 drops / minute, 30 μL / drop, at a temperature of 24°C, and react for 17 minutes until the solution changes from until the transparent slowly turns gray-black; finally, put the above-prepared solution in a boiling water bath at 100°C for 10 minutes...

Embodiment 3

[0029] Take 1.13 mg of vapreotide acetate (Wuhan Dongkangyuan Technology Co., Ltd.), dissolve it in 1 mL of hydrochloric acid solution with pH 7.0, and prepare a vapreotide acetate solution with a concentration of 1.0 mM, and place the vapreotide acetate solution in 67℃ metal bath for 24min; mix 500μL of vapreotide acetate solution after the metal bath with 500μL of 9.0mM silver nitrate solution (Tianjin Chemical Reagent Factory) and put it into a water bath constant temperature oscillator, control the speed at 126rpm, and the temperature at 24℃ Incubate under the condition for 26 h; add 90 μL of 100 mM sodium borohydride (produced by Beijing Zhongsheng Huateng Technology Co., Ltd.) dropwise for reduction, the dropping speed is 3 drops / min, 30 μL / drop, the temperature is 24 ° C, and the reaction is 18 min until the solution is from until the transparent slowly turns gray-black; finally, put the above-prepared solution in a boiling water bath at 100°C for 10 minutes, add 200 μL ...

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Abstract

A method for preparing silver-gold alloy nano spherical shells based on vapreotide acetate, which mainly comprises adding 0.91-1.13 mg vapreotide acetate per milliliter of hydrochloric acid solution to prepare a vapreotide acetate solution, which is stored at 65-67°C Treat for 20 to 24 minutes; add silver nitrate solution in a ratio of 1:3 to 9, put it in a water bath constant temperature oscillator at 24°C and incubate for 24 to 26 hours; the molar ratio of silver nitrate: sodium borohydride is 1:1 to 2 , then add the reducing agent sodium borohydride dropwise, and react at 24°C for 16-18min; then place it in a boiling water bath at 100°C for 10min, then add trichloride at a ratio of gold trichloride: silver nitrate molar ratio of 1:25-45 A gold solution is placed in a boiling water bath at 100° C. for 2 to 4 minutes to prepare silver-gold alloy nano spherical shells with a particle size of 90 to 110 nm. The invention has the advantages of easy control of appearance, simple operation, environmental protection and mild reaction conditions, and the prepared silver-gold alloy has uniform particle size and good dispersibility.

Description

technical field [0001] The invention belongs to the technical field of nanometer metal materials, and in particular relates to a preparation method of nanometer materials. Background technique [0002] The special properties of gold and silver nanoparticles have received extensive attention. Their surface properties, small size properties and excellent monodispersity have been used in various fields, in various chemical analysis, chemical catalysis, optical switches, sensors, There are potential application prospects in the fields of bioanalysis and biomedical detection. Many properties of gold and silver nanoparticles depend on the size and shape of the gold and silver nanoparticles. A large ratio of surface atoms can greatly enhance its surface activity; the unique surface structure, electronic state and atomic arrangement will make it have unique material properties, and can also promote some characteristic chemical reactions, leading to their catalytic properties Diffe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B22F1/00B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00B22F9/24B22F1/065B22F1/054
Inventor 高大威李彦集高发明边可新尹甜牛康刘欢
Owner YANSHAN UNIV
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