Unit splitting modulation method for focusing light through scattering medium

Abstract

The invention discloses a unit splitting modulation method for focusing light through a scattering medium and relates to the field of bioimaging. The method is characterized by including the step of finding an optimal phase and the step of quaternary splitting method modulation. In the step of finding the optimal phase, the phase change of 0-2pi is conducted on a spatial light modulator, phase modulation is conducted on incident plane waves, a CCD is adopted to receive a corresponding speckle pattern, the light intensity at the focusing position is calculated, comparison is conducted, and the phase value corresponding to the maximum light intensity is stored; In the step of quaternary splitting method modulation, a phase (optimal phase) making the output strength at the focusing position maximum is found in each unit, then the units are equally and sequentially divided into four parts, each unit adopts a previous optimized phase while continuing to search for better phase distribution, and in this way, the units can be subdivided and optimized into smaller subunits, even pixels of the spatial light modulator.

Description

Technical field [0001] The invention relates to the field of biological imaging, and a method for cell splitting modulation in which light is focused through a scattering medium. Background technique [0002] Brain imaging technology is a very important technology in the field of biomedicine. It is widely used in medical clinical practice. It plays a very important role in determining the location affected by the disease and diagnosing diseases in the human brain. The existing brain imaging methods are mainly There are electroencephalogram, magnetoencephalogram, magnetic resonance imaging, optical scattering imaging. Electroencephalogram is an image obtained by magnifying and recording the spontaneous biological potentials of the human brain. It is an effective method to detect brain diseases; magnetoencephalography is an accurate diagnosis by measuring extremely weak brain waves in the brain and recording them. Kind of diseases; the MRI method uses the principle of nuclear magn...

AI Technical Summary

Problems solved by technology

This method is simple and clear, easy to understand, easy to implement in operation, and has achieved good results, but the disadvantage is that it needs multiple iterations, takes a long time, and the signal-to-noise ratio is weak, so it is not easy to implement for dynamic media such as liquids.

The convergence speed of this method is faster than the one-by-one adjustment algorithm, and the signal-to-noise ratio is also higher, but because the phase modulation area is randomly selected, its convergence direction is random and uncertain

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