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Application of diosmetin in preparation of medicine used for treating type 2 diabetes mellitus

A geranialin and diabetes technology, applied in the field of medicine, can solve problems such as unseen type II diabetes, and achieve the effects of broadening the scope of use, improving insulin levels, and reducing fasting blood sugar levels and blood lipid levels.

Inactive Publication Date: 2017-06-13
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And there is no report on the treatment of type Ⅱ diabetes mellitus by diosmin (structural formula shown in formula 2)

Method used

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  • Application of diosmetin in preparation of medicine used for treating type 2 diabetes mellitus
  • Application of diosmetin in preparation of medicine used for treating type 2 diabetes mellitus
  • Application of diosmetin in preparation of medicine used for treating type 2 diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1. Effect of diosmin on blood sugar and insulin levels in type Ⅱ diabetic mice

[0018] Preparation of type Ⅱ diabetes mouse model: 70 Kunming mice were randomly divided into two groups, including 10 in the normal group and 60 in the model group. The normal group was fed with normal feed, and the model group was fed with high-sugar and high-fat feed. After 4 weeks, the normal group was intraperitoneally injected with pH4.2 citric acid-sodium citrate buffer solution; the model group was intraperitoneally injected with STZ (streptozotocin) solution (35 mg / kg) for 5 consecutive days. After 2 weeks, the fasting blood glucose (FBG) values ​​of the mice in each group were measured with a blood glucose meter. Among them, the mice with FBG>11.1mmol / L were successfully modeled type Ⅱ diabetes mellitus (T2DM) mice.

[0019] Detect the effect of diosmin on the blood sugar and insulin levels of type Ⅱ diabetic mice: 40 mice were randomly selected from the successfully mod...

Embodiment 2

[0029] Example 2. Effect of diosmin on blood lipid level in type Ⅱ diabetic mice.

[0030] The concentrations of low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TC) and total cholesterol (TG) in the serum of type 2 diabetic mice were measured by an automatic biochemical analyzer. The results are shown in Table 3.

[0031] Table 3. Effect of diosmin on blood lipid levels in type Ⅱ diabetic mice ( n=10)

[0032]

[0033] Note: Compared with the model group, *p<0.05 has a significant difference, and **p<0.01 has a very significant difference.

[0034] It can be seen from Table 3 that diosmin can significantly improve the blood lipid level, reduce the content of TC, TG and LDL, and increase the content of HDL-C at the same time.

Embodiment 3

[0035] Example 3. Effect of diosmin on insulin resistance in type Ⅱ diabetic mice

[0036] The expression of related proteins (p-IRS / IRS / PI3K / p-AKT / AKT) in the insulin resistance signaling pathway was detected by Western Blot. The results are shown in figure 1 shown.

[0037] Depend on figure 1 It can be seen that diosmin can significantly increase the phosphorylation of IRS and AKT proteins, and at the same time increase the expression of PI3K, and can significantly reduce the level of insulin resistance in diabetic mice.

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Abstract

The invention relates to application of diosmetin in preparation of a medicine used for treating type 2 diabetes mellitus. Researches show that diosmetin can obviously improve glycometabolism of the type 2 diabetes mellitus, can improve insulin level and lower blood lipid level, can be used for preparing a blood-glucose-lowering medicine and provides a new medicine for treatment of the type 2 diabetes mellitus, thereby having significance on the treatment of diabetes mellitus.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of diosmin in the preparation of medicines for treating type II diabetes. Background technique [0002] Diabetes Mellitus (DM) is a relatively common chronic metabolic disorder endocrine disease, which includes abnormal insulin secretion and peripheral tissue dysfunction. At present, the incidence of diabetes is second only to cardiovascular and cerebrovascular diseases and tumors, and is the third chronic disease that seriously endangers human health. According to statistics, as of 2010, the number of diabetic patients in the world has reached 285 million, of which type Ⅱ diabetes (T2DM) patients account for 90% of the total. By 2030, the number of diabetic patients in the world will exceed 400 million. Among them, in China, the number of diabetic patients is expected to reach 42.3 million in 2030. It can be seen that T2DM is showing a trend of rapid growth ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K9/20A61K9/48A61K9/16A61K9/08A61P3/10A61P3/06
CPCA61K9/0019A61K9/08A61K9/1652A61K9/2054A61K9/4866A61K31/352A61K47/26
Inventor 张保顺龚小保黄利挂陈竹
Owner SOUTHWEST UNIVERSITY
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