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Preparation method of radix salviae miltiorrhizae extracting solution by taking tanshinol as target object

A technology of extraction solution and target substance, which is applied in the field of preparation of Danshensu extract, can solve the problems of low yield of Danshensu, long extraction time, high equipment requirements, etc., and achieve simple and easy operation of the extraction process, stable content of Danshensu, stable Danshensu The effect of high content

Active Publication Date: 2017-08-01
吉林四长制药有限公司
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides a preparation method of Danshensu extract with Danshensu as the target object, in order to solve the problem that the conversion method of Danshensu in the extraction process of existing Danshen medicinal materials is complicated, the extraction time is long, organic solvents are used more, equipment requirements are high, and the conversion time is relatively high. Long, low yield of converted danshensu, incomplete conversion of salvianolic acid substances, and many organic solvent residues, the problem of low stability and safety of preparation of danshensu preparations

Method used

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  • Preparation method of radix salviae miltiorrhizae extracting solution by taking tanshinol as target object
  • Preparation method of radix salviae miltiorrhizae extracting solution by taking tanshinol as target object
  • Preparation method of radix salviae miltiorrhizae extracting solution by taking tanshinol as target object

Examples

Experimental program
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Effect test

Embodiment 1

[0016] (1), take the pre-treated Danshen medicinal material, add 8 times the volume, 10 times the volume of water to decoct twice, each time for 1.5h, 2h, combine the decoction, filter, the filtrate is concentrated to a relative density of 1.03, add 20 %lime solution to adjust the pH value to 11, let it stand for 1 hour, add 20% sulfuric acid solution to adjust the pH value to 5.0, let it stand for 24 hours, centrifuge, collect the centrifuged supernatant, heat and concentrate to a relative density of 1.20, add ethanol to the concentrate to make it contain alcohol When the alcohol content reaches 55%, stir for 15 minutes, then refrigerate for 24 hours, filter the alcohol precipitation solution, heat and concentrate to a relative density of 1.15, continue to add ethanol to make the alcohol content reach 65%, stir for 15 minutes, and refrigerate for 24 hours;

[0017] (2) After filtering the secondary alcohol precipitation solution, heat and concentrate to a relative density of 1...

Embodiment 2

[0021] (1) Take the pre-treated Salvia miltiorrhiza, add 8 times, 9 times, and 10 times the volume of water to decoct 3 times, each time for 1.5h, 1.5h, and 2h, combine the decoction, filter, and concentrate the filtrate To a relative density of 1.03, add 20% lime solution to adjust the pH value to 11, let it stand for 1.5 hours, add 20% sulfuric acid solution to adjust the pH value to 5.0, let it stand for 24 hours, centrifuge, collect the centrifuged supernatant, heat and concentrate to a relative density of 1.20, Add ethanol to the concentrated solution to make the alcohol content reach 60%, stir for 20 minutes, refrigerate and stand for 24 hours, filter the alcohol precipitation solution, heat and concentrate to a relative density of 1.15, continue to add ethanol to make the alcohol content reach 70%, stir for 20 minutes, and refrigerate Stand for 24 hours;

[0022] (2) After filtering the secondary alcohol precipitation solution, heat and concentrate to a relative density...

Embodiment 3

[0026] (1), take the pretreated Danshen medicinal material, add 8 times the amount, 10 times the amount, and 10 times the volume of water to decoct 3 times, each time for 1.5h, 2h, 2h, combine the decoction liquid, filter, and the filtrate is concentrated to The relative density is 1.03, add 20% lime solution to adjust the pH value to 11, let it stand for 2 hours, add 20% sulfuric acid solution to adjust the pH value to 5.0, let it stand for 24 hours, centrifuge, collect the centrifuged supernatant, heat and concentrate to a relative density of 1.20, concentrate Add ethanol to the liquid to make the alcohol content reach 65%, stir for 25 minutes, refrigerate and stand for 24 hours, heat and concentrate the alcohol precipitation solution to a relative density of 1.15 after filtering, continue to add ethanol to make the alcohol content reach 75%, stir for 25 minutes, and refrigerate set for 24 hours;

[0027] (2) After filtering the secondary alcohol precipitation solution, heat...

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Abstract

The invention relates to a preparation method of a radix salviae miltiorrhizae extracting solution by taking tanshinol as a target object, and belongs to the technical field of medicine extraction methods. The method comprises the following steps of processing by using a water extracting lime-sulphur method, as well as alcohol precipitation and water precipitation processing, removing macromolecular substances, such as a large number of protein and tannin, in an extracting solution, and then performing hydrolysis at proper temperature under the alkaline condition, so as to obtain a radix salviae miltiorrhizae extract which contains high concentration of the tanshinol, for preparing injection or medicines of other preparation forms containing the tanshinol. The preparation method provided by the invention has the advantages that the conversion ratio from salvianolic acids to the tanshinol is greatly improved, the target object taking the tanshinol as a main ingredient in the extract is realized, the extraction process is simple and easy to operate, the dosage of organic solvent is less, and the equipment requirements are simple; meanwhile, the macromolecular substances, such as the large number of protein and the tannin, in the extracting solution are removed, the prepared radix salviae miltiorrhizae extract is high in tanshinol content, is easy to store, the tanshinol content in the storage process is stable, and an effective raw material for preparing tanshinol preparations is provided.

Description

technical field [0001] The invention belongs to the technical field of medicine extraction methods, in particular to a preparation method of salvia miltiorrhiza extract. Background technique [0002] Danshensu is an active ingredient isolated from Salvia miltiorrhiza, a plant of the labiatae family. It has pharmacological effects such as expanding coronary arteries, controlling platelet aggregation, and improving microcirculation. For ischemic heart diseases such as angina pectoris, it has a fast onset of action and high bioavailability, and has extremely high clinical value. At present, Danshensu is mainly derived from the herbal medicine Danshen. The content of free Danshensu in Danshen medicinal material is low, and the extraction conversion rate is low. The composition of Danshen extract obtained by simple water extraction process is complex. Acid A is also called danshensu. Salvianic acid B is formed by the condensation of 3 molecules of danshensu and 1 molecule of caf...

Claims

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Application Information

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IPC IPC(8): C07C51/367C07C59/52
CPCC07C51/367C07C59/52
Inventor 欧阳玉平刘慧赵志英
Owner 吉林四长制药有限公司
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