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Application of anisodine to preparation of drugs for preventing or treating renal fibrosis

A technology of renal fibrosis and anisodine, which is applied in the field of medicine, can solve problems such as renal fibrosis of anisodine that has not been recorded, and achieve the effect of improving proliferation and activation

Inactive Publication Date: 2017-08-18
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, there is no literature report that anisodine can be used to treat renal fibrosis

Method used

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  • Application of anisodine to preparation of drugs for preventing or treating renal fibrosis
  • Application of anisodine to preparation of drugs for preventing or treating renal fibrosis
  • Application of anisodine to preparation of drugs for preventing or treating renal fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0013] Example: Therapeutic effect of anisodine hydrobromide on renal fibrosis model rats

[0014] 1. Experimental plan

[0015] 1. Materials and methods

[0016] 1.1 Experimental animals: 40 clean healthy male SD rats aged 6-8 weeks, purchased from Beijing Huafukang Technology Co., Ltd. The experimental animals were kept in the animal center of the State Key Laboratory of Biotherapy, Sichuan University, in an environment with constant temperature, constant humidity and full air circulation and filtration.

[0017] 1.2 Materials: anisodine hydrobromide (99% pure), purchased from China Institute for the Control of Pharmaceutical and Biological Products, rabbit anti-rat α-smooth muscle actin antibody, rabbit anti-rat transforming growth factor-β antibody were purchased from Hangzhou Huaan biology.

[0018] 1.3 Method:

[0019] 1.31 Establishment of animal model: Rats were anesthetized by intraperitoneal injection of 2% pentobarbital sodium (50 mg / kg), fixed in the right late...

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Abstract

The invention belongs to the field of medicine and particularly relates to application of anisodine to preparation of drugs for preventing or treating renal fibrosis. The technical problem to be solved is to provide novel application of the anisodine, particularly application of the anisodine to preparation of the drugs for preventing or treating the renal fibrosis. Specifically, the anisodine has the efficacies of decreasing the level of Scr and BUN in serum and the level of alpha-SMA and TGF-beta protein in renal tissues and promoting or improving fibrous tissue proliferation in renal interstitium, which indicates that the anisodine is capable of protecting and improving renal interstitial fibrosis. The anisodine serving as an active ingredient is preferably selected from anisodine hydromide. Experiments prove that the anisodine hydromide is capable of preventing or treating the renal fibrosis and improving the renal fibrosis by inhibiting proliferation and activation of myofibroblasts in the renal tissues, and accordingly a novel selection for clinical prevention and treatment of the renal fibrosis is offered.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of anisodine in the preparation of medicines for preventing or treating renal fibrosis. Background technique [0002] Renal fibrosis is the ultimate common pathway and pathological basis for the development of various chronic kidney diseases (CKD) to end-stage renal failure, and is one of the important diseases that seriously endanger human life and health. Renal interstitial fibrosis is characterized by the progressive deposition of a large amount of extracellular matrix (ECM) components in the renal tubules and the capillary space around the tubules, destroying the normal tubular and renal interstitial structures, and eventually leading to the complete loss of kidney function. device function. The pathogenesis of renal interstitial fibrosis is very complex, involving processes such as cell phenotype conversion, oxidative stress, inflammatory response, and in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/439A61P13/12
CPCA61K31/439
Inventor 杨金亮敖广宇
Owner SICHUAN UNIV
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