Separating and enriching microfluidic chip with high flux for tumor cells

Abstract

The invention discloses a separating and enriching microfluidic chip with high flux for tumor cells. The separating and enriching microfluidic chip comprises four functional modules, namely an upper flow guide module (1), a flow rate adjusting module (2), a high-flux inertial separating and enriching module (3) and a lower flow guide module (4), wherein the upper flow guide module (1) is used for guiding normal saline and blood to a target position; the flow rate adjusting module (2) is used for providing flow rate required by separating of tumor cells and blood cells; the high-flux inertial separating and enriching module (3) is used for improving separating speed by integrating a plurality of inertial separating flow channels; the lower flow guide module (4) is used for collecting the blood cells and tumor cells to different exits. The separating and enriching microfluidic chip has the advantages that the functions of flow rate automatic control and tumor cell separating and enriching are realized, the other auxiliary equipment is not needed, the low-cost and high-flux separating on the tumor cells circulating in the blood is realized, and the important value and commercial prospect are realized in the cancer diagnosis, prognosis evaluation and the like.

Description

technical field [0001] The invention belongs to the technical fields of drug delivery system, biomedical diagnosis and integrated microchip experiment, and relates to a high-throughput sorting and enriching microfluidic chip for tumor cells, specifically, an integrated flow control and cancer cell sorting chip. Function-enriched microfluidic chip technology. Background technique [0002] Cancer, also known as malignant tumor, is a disease caused by the abnormal mechanism of controlling cell growth and proliferation. Malignant tumors grow rapidly and destroy normal tissues and organs of the human body, eventually causing death of the patient. With the change of people's living habits and living environment, the current situation of cancer is more serious, and it has become the most important problem affecting public health in the world. Modern medicine has found that in the early stage of cancer recurrence and metastasis, tumor cells will fall off from the original tumor fo...

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Problems solved by technology

[0004] In order to solve the above problems, the present invention discloses a microfluidic chip for high-throughput sorting and enrichment of tumor cells, which can solve the problems of low density of circulating tumor cells in blood (only 1-100 in 1mL of blood), difficulty in detection, etc. , to achieve efficient and rapid separation of tumor cells and blood cells in blood

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