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A kind of polypeptide with antibacterial and anti-inflammatory activity and its application

An active and antibacterial agent technology, applied in the field of molecular biology, can solve the problems of low content of active polypeptide Lunasin, low activity, unfavorable separation and purification, etc., and achieve the effect of easy separation and purification, high activity, and efficient expression

Active Publication Date: 2020-09-22
广东尚品汇生物科技有限公司
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0004] However, the naturally isolated active polypeptide Lunasin has the defects of low content and low activity, which is not conducive to separation and purification, which limits its application

Method used

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  • A kind of polypeptide with antibacterial and anti-inflammatory activity and its application
  • A kind of polypeptide with antibacterial and anti-inflammatory activity and its application
  • A kind of polypeptide with antibacterial and anti-inflammatory activity and its application

Examples

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Embodiment Construction

[0019] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments, but should not be construed as a limitation of the present invention. The experimental methods in the following examples, unless otherwise specified, are conventional methods, and the materials, reagents, etc. used in the following examples, unless otherwise specified, can be obtained from commercial sources.

[0020] The present invention provides a polypeptide with antibacterial and anti-inflammatory activity (hereinafter referred to as G-Lunasin), the nucleotide sequence of the polypeptide is shown in SEQ ID NO.1, the amino acid sequence is shown in SEQ ID NO.2, the The polypeptide is to improve the amino acid structure of the active polypeptide Lunasin, adding amino acid residues to the Lunasin amino acid sequence shown in SEQ ID NO.3, increasing the activity of the original Lunasin and the expression efficiency in cells, and reducing the co...

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Abstract

The invention belongs to the technical field of molecular biology, and particularly relates to polypeptide with antibacterial anti-inflammatory activity and application thereof. The nucleotide sequence of the polypeptide is shown as SEQ ID NO.1, and the amino acid sequence is shown as SEQ ID NO.2. The polypeptide with the antibacterial anti-inflammatory activity is obtained through modification on the basis of a polypeptide Lunasin amino acid structure, and can be efficiently expressed in cells; the separation and the purification are easy; the activity is higher.

Description

technical field [0001] The invention belongs to the technical field of molecular biology, and specifically relates to a polypeptide with antibacterial and anti-inflammatory activities and its application. Background technique [0002] Antimicrobial peptides are a type of small molecular defense peptides synthesized by organisms, which have broad-spectrum bactericidal effects, and have strong killing effects on both Gram-negative and Gram-positive bacteria, especially against certain fungi and mycoplasma. Drug-resistant bacteria also have a good killing effect and are important members of the animal's innate immune system. General antibiotics play a role by blocking the biosynthesis of biological macromolecules, while antibacterial polypeptides can perforate the bacterial cell membrane to form ion channels, causing damage to the bacterial cell membrane structure, causing a large amount of intracellular water-soluble substances to leak out, and eventually lead to Bacteria die...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/415C12N15/70C12N15/29C12N1/21A61K38/16A61P31/04
CPCA61K38/00C07K14/415C12N15/70
Inventor 强黎明卢奎董雪茹吕名秀李玥
Owner 广东尚品汇生物科技有限公司
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