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Emulsion composition containing 25-hydroxyvitamin D3 and preparation method thereof

A technology of hydroxyvitamin and emulsion composition, which is applied in the field of animal health care, can solve the problems of demulsification, poor product stability, high viscosity, etc., and achieve the effect of improving bone density or bone strength, good preparation stability, and good stability

Active Publication Date: 2017-10-27
ACT PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wherein, its emulsion dosage form is the state that the microencapsulated oil composition has not been spray-dried, and its viscosity is very high, is unfavorable for practical application
Moreover, 25-hydroxyvitamin D3 is unstable under conventional preparation conditions, resulting in a time-dependent loss of activity per unit dose. Especially at higher temperatures, the active ingredient is easy to degrade, and this degradation is harmful to 25-hydroxyvitamin D3 during use. Dosage of Vitamin D3 Adversely Affects
Chinese patent 201610070588.7 discloses a quick-acting energy-enhancing compound vitamin microemulsion preparation for pigs. The cost of medium-chain triglycerides in more than 80% of the composition is relatively high, and the obtained water-in-oil microemulsion will be diluted during use. It is inconvenient to use due to demulsification, it is necessary to prevent rancidity during storage, the stability of the product is poor, and the requirements for the preparation, storage and transportation of the product are more stringent

Method used

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  • Emulsion composition containing 25-hydroxyvitamin D3 and preparation method thereof
  • Emulsion composition containing 25-hydroxyvitamin D3 and preparation method thereof
  • Emulsion composition containing 25-hydroxyvitamin D3 and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The composition of the emulsion composition containing 25-hydroxyvitamin D3 is shown in Table 2:

[0053] Table 2

[0054] Composition

Prescription amount / g

Prescription ratio / %

effect

25-Hydroxyvitamin D3

1.584

0.176

active ingredient

medium chain triglycerides

63.0

7.00

oil dispersed phase

2,6-di-tert-butyl-4-methylphenol

9.0

1.00

antioxidant

Glyceryl monolinoleate

21.9

2.44

lipophilic emulsifier

Tween-60

41.1

4.50

Hydrophilic emulsifier

water

763.4

84.8

continuous phase

total

about 900g

100

--

[0055] The above-mentioned emulsion composition containing 25-hydroxyvitamin D3 is prepared by the following process:

[0056] 1. Oil phase preparation:

[0057] Use a water bath to maintain the temperature of the water bath at 70°C, add medium-chain triglycerides into the beaker, and check the temperature to 70°C; add the prescribe...

Embodiment 2

[0072] The composition of the emulsion composition containing 25-hydroxyvitamin D3 is shown in Table 4:

[0073] Table 4

[0074]

[0075] The above-mentioned emulsion composition containing 25-hydroxyvitamin D3 is prepared by the following process:

[0076] 1. Oil phase preparation:

[0077] Use a water bath to maintain the temperature of the water bath at 70°C, add medium-chain triglycerides into the beaker, and check the temperature to 70°C; add the prescribed amount of 2,6-di-tert-butyl-4-methylphenol into it, and use magnetic stirring equipment Stir to dissolve, stirring for 15 minutes; add prescription amount of 25-hydroxyvitamin D3, stir to dissolve, stirring for 60 minutes.

[0078] 2. Preparation of emulsifier

[0079] Mix the monolinoleic acid glyceride and Tween-20 of the prescribed amount with the beaker evenly;

[0080] 3. Colostrum preparation

[0081] Pour the prescribed amount of emulsifier into the oil phase and stir to form colostrum for 5 minutes;

...

Embodiment 3

[0092] Stability test: Place the samples prepared in Example 1 and Example 2 under the conditions of 25°C and 60% RH, and investigate their content, properties, pH and other items.

[0093] The stability results are shown in Table 6:

[0094] Table 6

[0095]

[0096] The results show that both the implementation case 1 and the implementation case 2 have good stability, and they are stable for 90 days under accelerated conditions of 25°C and 60% RH.

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Abstract

The invention discloses an emulsion composition containing 25-hydroxyvitamin D3 and a preparation method thereof. The emulsion composition is prepared from an active ingredient 25-hydroxyvitamin D3, a lipophilic emulsifier, a hydrophilic emulsifier, an antioxidant, a disperse-phase oil-phase solvent and a continuous-phase aqueous-phase solvent. According to the invention, a more stable oil-in-water type emulsion dosage form is prepared by optimizing the emulsifier dosage and proportion and adjusting the types and proportions of the aqueous phase and oil phase; a product has high stability and is convenient to prepare, transport and store and more suitable for industrial application; the emulsion prepared by the preparation method can maintain relatively high preparation stability and can be dispersed in drinking water at a fixed dosage; thus, the 25-hydroxyvitamin D3 can be applied to feed for poultry and pigs more conveniently, and improves the bone density or bone strength as a nutritional supplement for the poultry and pigs.

Description

technical field [0001] The invention belongs to the field of animal health care, and in particular relates to an emulsion composition containing 25-hydroxyvitamin D3 and a preparation method thereof. Background technique [0002] Vitamin D (eg, ergocalciferol D2 and cholecalciferol D3) is a group of fat-soluble compounds defined by their biological activity, which promotes bone resorption and also regulates the functions of the cardiovascular, immune, and muscular systems. Epidemiological studies have found associations between vitamin D intake and its effects on blood pressure or glucose metabolism. Vitamin D activity is controlled by negative feedback from parathyroid hormone. Vitamin D deficiency causes rickets in children and osteomalacia in adults. However, toxicity may occur after chronic intake of more than 100 times the recommended daily allowance (5-15 μg or 200-600 IU) of vitamin D for several months, and blood calcium may occur at a blood concentration of more t...

Claims

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Application Information

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IPC IPC(8): A23K20/174A23K50/30A23K50/75A23K40/30
CPCA23K20/174A23K40/30A23K50/30A23K50/75
Inventor 单鹏达张德臣
Owner ACT PHARMA CO LTD
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