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Medicine composition for treating central nervous system diseases as well as preparation method and application of medicine composition

A technology of central nervous system and composition, which is applied in the direction of nervous system diseases, drug combination, pharmaceutical formula, etc., can solve the problems of unspecified active ingredients, achieve the effect of improving cognitive function, improving learning and memory ability, and reducing oxidation products

Active Publication Date: 2017-11-03
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the Rhodiola rosea extract in this patent only extracts the effective part, and does not specify the specific active ingredients

Method used

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  • Medicine composition for treating central nervous system diseases as well as preparation method and application of medicine composition
  • Medicine composition for treating central nervous system diseases as well as preparation method and application of medicine composition
  • Medicine composition for treating central nervous system diseases as well as preparation method and application of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Weigh 5 g of raw materials salidroside, 1 g of astragalus polysaccharide, add 6 g of auxiliary materials starch to granulate, 1 g of magnesium stearate, 5 g of dextrin, and 5 g of microcrystalline cellulose, uniformly prepare granules, and press into tablets to obtain tablets.

Embodiment 2

[0021] Weigh 60 g of salidroside and 30 g of astragalus polysaccharide, add 100 g of auxiliary materials starch to granulate, 5 g of magnesium stearate, 50 g of dextrin, and 50 g of microcrystalline cellulose, uniformly prepare granules, and press into tablets to obtain tablets.

Embodiment 3

[0023] Weigh 8 g of salidroside and 3 g of astragalus polysaccharide, add 10 g of auxiliary materials starch to granulate, 2 g of magnesium stearate, 5 g of dextrin, and 5 g of microcrystalline cellulose, uniformly prepare granules, and press into tablets to obtain tablets.

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PUM

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Abstract

The invention discloses medicine composition for treating central nervous system diseases. The medicine composition is prepared from, by weight, 5-60 parts of salidroside and 1-30 parts of hedysarum polybotrys saccharide. The invention further provides a preparation method of the medicine composition. The invention further provides a preparation method and a specific application of the medicine composition. Pharmacological experiments prove that the medicine composition can remarkably improve the learning and memory capacity of a D-galactose induced dementia mouse model by reducing oxidative products in brain tissue and improving activity of antioxidant enzymes in the brain and can remarkably improve the cognitive function of a vascular dementia rat. Besides, the medicine composition has an anti-hyperlipidemic effect to different extents after the medicines are matched.

Description

technical field [0001] The invention belongs to the field of pharmacy, relates to a pharmaceutical composition for treating diseases of the central nervous system, in particular to a method for treating and alleviating senile dementia (Alzheimer's disease), mild cognitive dysfunction, vascular dementia and its A pharmaceutical composition for early vascular cognitive impairment, its preparation method and application. Background technique [0002] Alzheimer's disease (AD) is a neurological disease characterized by senile plaques, neurofibrillary tangles, vascular amyloidosis and neuronal loss, and clinically characterized by progressive cognitive dysfunction and behavioral impairment. degenerative disease. Alzheimer's disease is one of the main forms of dementia, accounting for 42%-81% of the total incidence of dementia. The latest report of the World Alzheimer Association (ADI) pointed out that in 2015, there were 468 million senile dementia patients worldwide. The prevale...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K31/7032A61P25/28
CPCA61K31/7032A61K31/715A61K2300/00
Inventor 张占军卫东锋马涛
Owner BEIJING NORMAL UNIVERSITY
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