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Application of regulatory T cells in preparing drug for treating autoimmune diabetes and expanding cultivation solution and method thereof

A diabetes drug and regulatory technology, applied in the field of cell therapy to achieve good curative effect

Active Publication Date: 2017-11-17
CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The invention provides an application of regulatory T cells in the preparation of drugs for treating immune diabetes, and its expansion solution and expansion method, so as to solve the technical problems of drugs for treating immune diabetes

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  • Application of regulatory T cells in preparing drug for treating autoimmune diabetes and expanding cultivation solution and method thereof
  • Application of regulatory T cells in preparing drug for treating autoimmune diabetes and expanding cultivation solution and method thereof
  • Application of regulatory T cells in preparing drug for treating autoimmune diabetes and expanding cultivation solution and method thereof

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Embodiment Construction

[0027] The embodiments of the present invention will be described in detail below with reference to the accompanying drawings, but the present invention can be implemented in many different ways defined and covered by the claims.

[0028] A preferred embodiment of the present invention provides an application of regulatory T cells in the preparation of drugs for treating immune diabetes.

[0029] The present invention has the following beneficial effects: the application of the above-mentioned regulatory T cells in the preparation of drugs for the treatment of immune diabetes, through the targeted research on the pathogenesis of autoimmune diabetes and regulatory T cells, the applicant found that the regulatory T cells in the treatment of self Immune diabetes has a good effect. In clinical trials, 4 cases of autoimmune diabetes have been successfully treated. The current follow-up results suggest that this treatment method is safe.

[0030] Another aspect of the present invent...

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Abstract

The invention discloses application of regulatory T cells in preparing a drug for treating autoimmune diabetes and an expanding cultivation solution and method thereof. The expanding cultivation solution of the regulatory T cells is prepared from, by volume, 35.274-42.69 parts of serum-free cultivation solutions, 1.25-2.5 parts of 4-(2-hydroxyerhyl)piperazine-1-erhanesulfonic acid buffer solution, 0.5-1 part of penicillin-streptomycin solution, 0.5-1 part of L-glutamine, 0.05-0.1 part of 2-mercaptoethanol, 0.00769-0.01154 part of recombinant interleukin-2, 0.001-0.01 part of rapamycin and 5-10 parts of AB serum. According to the application of the regulatory T cells in preparing the drug for treating the autoimmune diabetes, through targeted research on the regulatory T cells and the pathogenesis of the autoimmune diabetes, applicants find that the regulatory T cells has relatively good therapeutic effects at the aspect of treating the autoimmune diabetes.

Description

technical field [0001] The invention relates to the field of cell therapy, in particular to the application of regulatory T cells in the preparation of drugs for treating immune diabetes. In addition, the present invention also relates to an expansion culture solution and expansion method comprising the above-mentioned regulatory T cells. Background technique [0002] Autoimmune diabetes mellitus (ADM) is an autoimmune disease mainly mediated by T cells, involving multiple pathways and various immune cells. Taking the pathogenesis of ADM as a therapeutic target and improving the body's autoimmune state is an ideal treatment for fundamentally curing ADM. Regulatory T cells (regμlatory T cells, Treg) are a group of immune cell subsets with immunoregulatory functions, which have the ability to suppress the proliferation of autoimmune cells (CD4+CD25-T), and mainly play a role in the feedback regulation of the immune system. inhibition. Regulatory T cell therapy (Treg) can re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/17C12N5/0783A61P3/10A61P37/02
CPCA61K35/17C12N5/0637C12N2500/30C12N2500/32C12N2500/44C12N2501/23
Inventor 周智广俞海波
Owner CENT SOUTH UNIV
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