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Isaria cicadae miq extract and application thereof in preparing hypolipidemic drug

An extract, the technology of cicada flower, applied in the field of traditional Chinese medicine, can solve the problems that the effect of cicada flower on lowering blood fat has not yet been seen, and achieve the effect of good effect and blood fat lowering effect

Active Publication Date: 2017-12-29
江西永昇制药股份有限公司
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Problems solved by technology

However, there is no relevant report that Cicada has hypolipidemic effect

Method used

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  • Isaria cicadae miq extract and application thereof in preparing hypolipidemic drug
  • Isaria cicadae miq extract and application thereof in preparing hypolipidemic drug
  • Isaria cicadae miq extract and application thereof in preparing hypolipidemic drug

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Embodiment Construction

[0016] The present invention will be further described below in conjunction with specific embodiments, so that those skilled in the art can better understand the present invention, but the present invention is not limited thereby.

[0017] One, the preparation of Cicada flower extract

[0018] Step 1: Take the sun-dried Cicada, use 60% ethanol as a solvent, warm-immerse and extract at 50°C, extract 4 times, each extraction time is 4 hours, and the amount of solvent used each time is 12% of the weight of Cicada. times; filter, combine extracts, recover ethanol, concentrate, dry to obtain Cicada flower extract A;

[0019] In the 2nd step, add 12 times the amount of water to dissolve the Cicada flower extract A obtained in the 1st step, filter to obtain medicinal solution A and precipitate A; use high-speed countercurrent chromatography (HSCCC) to dissolve the precipitate A in a volume ratio of 3 : 2:3:1 cyclohexane-ethyl acetate-n-butanol-water as solvent, separation and purifi...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine and relates to a preparation method of isaria cicadae miq extract and application thereof in preparing hypolipidemic drug. Mouse experiments find that the extract can effectively lower total cholesterol (TC), triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels in serum of hyperlipidemia mice, so that the extract has good lipid-lowering effect.

Description

technical field [0001] The invention discloses a cicada flower extract and its application in the preparation of blood lipid-lowering medicine, which belongs to the technical field of traditional Chinese medicine. Background technique [0002] Blood lipid is a general term for neutral fats (triglycerides and cholesterol) and lipids (phospholipids, glycolipids, sterols, steroids) in plasma. Hyperlipidemia refers to elevated levels of one or more of total cholesterol, triglycerides, and low-density lipoproteins in plasma. Medical research shows that hyperlipidemia is closely related to cardiovascular disease and is one of the main causes of atherosclerosis. [0003] At present, with the rapid development of the economy, great changes have taken place in people's diet structure, the intake rate of high-calorie foods such as animal fat has increased, coupled with the changes in psychological factors caused by the accelerated pace of life, the number of people with hyperlipide...

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Application Information

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IPC IPC(8): A61K36/068A61P3/06A61K35/64
CPCA61K36/068A61K2236/333A61K2236/39A61K2236/55A61K35/63
Inventor 杜耀兵
Owner 江西永昇制药股份有限公司
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