Bionic heart patch repairing material and preparation method thereof
A technology for repairing materials and hearts, applied in the field of bionic materials, can solve problems such as limiting the development of myocardial patches, and achieve effects that are conducive to repair, accumulation, and prevention of arrhythmia
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[0029] (1) Preparation of functionalized hyaluronic acid
[0030] Weigh a certain amount of methacrylylated hyaluronic acid and dissolve it in distilled water to prepare a methacrylylated hyaluronic acid solution with a mass concentration of 5%. Weigh a certain amount of 1-(3-dimethylaminopropyl base)-3-ethylcarbodiimide (EDC) and N-hydroxysuccinimide (NHS) were sequentially dissolved in distilled water to prepare an EDC / NHS solution, in which 1-(3-dimethylaminopropyl base)-3-ethylcarbodiimide (EDC) at a concentration of 6 mg / mL and N-hydroxysuccinimide (NHS) at a concentration of 1 mg / mL; methacrylylated hyaluronic acid solution and Mix equal volumes of EDC / NHS solution, stir at room temperature for 30-45min, then add an equal volume of 2-(2-pyridyldithio)ethylamine hydrochloride solution with a concentration of 0.3 mg / mL, and stir at room temperature for 1- 2h, finally add m methacryloyl hyaluronic acid according to the mass ratio:mREDV short peptide=1:0.025 Add REDV short ...
Embodiment 1
[0038]According to the present invention, a kind of bionic heart patch repair material is prepared according to the above method, wherein: the REDV short peptide used in the preparation process has an amino acid sequence of Arg-Glu-Asp-Val, and the gold nanorods used have an aspect ratio of 2.5, the size (length × width) is 30 × 10nm; the computer-aided software used is AutoCAD, the 3D printer used is 3D systems company, the model is 3Dsystems ProX photocuring printer; the functionalized hyaluronic acid 30 1 part, 5 parts of methacrylated gelatin, 1 part of gold nanorod, 0.05 part of human adipose-derived mesenchymal stem cell, and 0.1 part of photoinitiator.
Embodiment 2
[0040] According to the present invention, a kind of bionic heart patch repair material is prepared according to the above method, wherein: the REDV short peptide used in the preparation process has an amino acid sequence of Arg-Glu-Asp-Val, and the gold nanorods used have an aspect ratio of 2.5, the size (length × width) is 30 × 10nm; the computer-aided software used is AutoCAD, the 3D printer used is 3D systems company, the model is 3Dsystems ProX photocuring printer; the functionalized hyaluronic acid 45 10 parts of methacrylated gelatin, 2.5 parts of gold nanorods, 0.075 parts of human adipose-derived mesenchymal stem cells, and 0.25 parts of photoinitiator.
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