Use of salidroside in preparation of complement inhibitor drugs

A technology of complement inhibitor, salidroside, applied in the field of salidroside, which can solve the problems of unreported salidroside and lack of clinical application, etc., and achieve the effect of clear drug effect and controllable quality

Inactive Publication Date: 2018-01-26
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a drug, the clinical application of salidroside is still lacking, and there are few reports about the clinical application of salidroside in various aspects, and there are no reports about salidroside acting on the complement system to treat inflammatory diseases caused by excessive activation of the complement system

Method used

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  • Use of salidroside in preparation of complement inhibitor drugs
  • Use of salidroside in preparation of complement inhibitor drugs
  • Use of salidroside in preparation of complement inhibitor drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 The preparation of the medicine that inhibits the complement system of the present invention

[0033] Take commercially available salidroside (purity is 98%), add pharmaceutically acceptable adjuvants or auxiliary ingredients, and prepare it into a medicament.

[0034] Prove the beneficial effect of the present invention below by concrete pharmacodynamics test.

experiment example 2

[0104] Experimental Example 2 Salidroside inhibits the activation of the complement system in rats with ischemic brain injury

[0105] 1 Experimental materials

[0106] 1.1 Experimental animals

[0107] SPF grade SD rats, male, weighing 280±20g, 144, provided by the Experimental Animal Center of Fujian University of Traditional Chinese Medicine, purchased from Shanghai Slack Experimental Animal Co., Ltd., certificate number: 2007000509960, license number: SCXK (Shanghai ) 2012-0005, used for experiments after adaptive feeding for 7 days.

[0108] 1.2 Experimental drugs

[0109] Salidroside (purity: 98%), commercially available.

[0110] 1.3 Experimental reagents

[0111] Table 5 Experimental Reagents

[0112]

[0113]

[0114] Table 6 Experimental Instruments

[0115] name

model

manufacturers

Heated Incubators

DHP-9052

Shanghai Yiheng

fast mixer

SK-1

Changzhou Guohua

High-speed desktop refrigerated centrifuge ...

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PUM

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Abstract

The invention provides a new use of salidroside, and specifically, relates to a use in preparation of complement inhibitor drugs. The salidroside drug can act on a lectin pathway and a classical pathway in a complement system, directly inhibits the activation of complement systems of nerve cells, vascular endothelial cells and other brain cells, plays a neuroprotective role, can effectively treatneuroinflammatory or neurodegenerative diseases, has the advantages of clear drug efficacy, controllable quality and safety, and provides a new choice for the clinic.

Description

technical field [0001] The present invention relates to the new application of salidroside, specifically, the application in the preparation of complement inhibitor drugs. Background technique [0002] The complement system is a group of proteins that exist in human and animal body fluids and on the surface of cells, are biologically active after activation, and can mediate immune and inflammatory responses. The complement system is widely involved in the body's microbial defense response and immune regulation, and can also mediate the damage response of immunopathology. It is an effector system and effect amplification system with important biological functions in the body. [0003] The complement system not only plays an important defense role in the body, but also plays an important role in various physiological activities and homeostasis. It can participate in the catabolism of immune complexes, the removal of necrotic cells, and the regulation of adaptive immune respons...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61P29/00A61P25/28A61P25/00
Inventor 陈立典洪桂祝褚克丹赖文芳郑振威谢秀利张小琴
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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