Proton pump inhibitor, preparation method and application

A technology of proton pump inhibitor and reaction solution, applied in the field of oral care, can solve the problems of complicated preparation method, poor drug effect, low product purity, etc., and achieves outstanding economic and social benefits, increased convenience, and high yield Effect

Pending Publication Date: 2022-03-22
重庆大学附属三峡医院
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Problems solved by technology

[0004] Through the above analysis, the existing problems and defects of the prior art are: currently used drugs are not effective or have large side effects; at the same time, the existing proton pump inhibitor preparation method is cumbersome, high in cost, low in yield, and low in product purity.

Method used

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  • Proton pump inhibitor, preparation method and application

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preparation example Construction

[0029] like figure 1 As shown, the preparation method of the proton pump inhibitor provided by the embodiments of the present invention comprises the following steps:

[0030] S101, 2-mercapto-5-methoxybenzimidil reacts with 2-chloromethyl-3,5-dimethyl-4-methoxypyridine hydrochloride in sodium hydroxide solution to form Ogilvy Lasulfide intermediate;

[0031] S102, after dissolving the omeprazole sulfide intermediate in ethanol, reacting with a catalyst containing ammonium molybdate and cumene hydroperoxide to obtain an omeprazole reaction solution;

[0032] S103, purifying the obtained omeprazole reaction solution; adding sodium carbonate to the purified omeprazole reaction solution and mixing evenly, and adjusting the pH value with aqueous acetic acid;

[0033] S104, adding omeprazole seed crystals to the adjusted solution, stirring evenly, continuing to drop acetic acid aqueous solution to adjust the pH to 8.5, and leaving it to age for 1 hour;

[0034] S105, filtering t...

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Abstract

The invention belongs to the technical field of oral care, and discloses a proton pump inhibitor, a preparation method and application, and the proton pump inhibitor is omeprazole. The traditional Chinese medicine has the advantages of new use, small side effect, quick response and good curative effect. The proton pump inhibitor and omeprazole provided by the invention are high in curative effect, convenient to take, capable of effectively treating oral ulcer, huge in clinical significance and outstanding in economic and social benefits. The preparation process of the proton pump inhibitor is simple, the cost is low, the reaction conditions are not harsh, the synthesis efficiency is high, the yield is high, biological enzyme does not need to participate, the safety is high, and meanwhile, the purity of the obtained proton pump inhibitor is effectively improved by purifying the omeprazole solution. According to the method, the convenience of production operation is remarkably improved, the operation steps are reduced, the production energy consumption and time cost are reduced, the production cost is reduced, the production efficiency is improved, and the production economy is high.

Description

technical field [0001] The invention belongs to the technical field of oral care, and in particular relates to a proton pump inhibitor, a preparation method and an application. Background technique [0002] At present, oral ulcer, commonly known as "oral ulcer", is a common ulcerative injury disease that occurs in the oral mucosa. It is more common in the inner lip, tongue, tongue abdomen, buccal mucosa, vestibular groove, soft palate and other parts. The mucosa in these parts lacks keratin. Poor stratification or keratinization. Tongue ulcers refer to oral ulcers that occur on the tongue and the abdomen of the tongue. When oral ulcers attack, the pain is severe, and the local burning pain is obvious. In severe cases, it will also affect eating and speaking, causing great inconvenience to daily life; Symptoms such as swollen lymph nodes. [0003] The occurrence of oral ulcers is the result of a combination of many factors, including local trauma, mental stress, food, drug...

Claims

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Application Information

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IPC IPC(8): A61K31/4439A61P1/02C07D401/12
CPCA61K31/4439A61P1/02C07D401/12
Inventor 巫贵成魏灼丽陈新宋强谭祥章文锦罗小河张先祥郎春辉刘畅安选
Owner 重庆大学附属三峡医院
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