Proton pump inhibitor, preparation method and application
A technology of proton pump inhibitor and reaction solution, applied in the field of oral care, can solve the problems of complicated preparation method, poor drug effect, low product purity, etc., and achieves outstanding economic and social benefits, increased convenience, and high yield Effect
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[0029] like figure 1 As shown, the preparation method of the proton pump inhibitor provided by the embodiments of the present invention comprises the following steps:
[0030] S101, 2-mercapto-5-methoxybenzimidil reacts with 2-chloromethyl-3,5-dimethyl-4-methoxypyridine hydrochloride in sodium hydroxide solution to form Ogilvy Lasulfide intermediate;
[0031] S102, after dissolving the omeprazole sulfide intermediate in ethanol, reacting with a catalyst containing ammonium molybdate and cumene hydroperoxide to obtain an omeprazole reaction solution;
[0032] S103, purifying the obtained omeprazole reaction solution; adding sodium carbonate to the purified omeprazole reaction solution and mixing evenly, and adjusting the pH value with aqueous acetic acid;
[0033] S104, adding omeprazole seed crystals to the adjusted solution, stirring evenly, continuing to drop acetic acid aqueous solution to adjust the pH to 8.5, and leaving it to age for 1 hour;
[0034] S105, filtering t...
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