A group of markers for predicting the risk of metastasis of nasopharyngeal carcinoma and its application

A marker and technology of nasopharyngeal carcinoma, which is applied in the direction of recombinant DNA technology, biochemical equipment and methods, and microbial measurement/testing, can solve the problems of insufficient treatment intensity of patients and distinguish the risk of metastasis of patients, so as to achieve good clinical drug use, Accurately Predicted Effects

Active Publication Date: 2020-02-21
SUN YAT SEN UNIV CANCER CENT
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Problems solved by technology

Obviously, relying solely on clinical staging cannot accurately distinguish the risk of metastases in patients, so as to give targeted treatment, some patients may receive over-treatment, while others may receive insufficient treatment intensity

Method used

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  • A group of markers for predicting the risk of metastasis of nasopharyngeal carcinoma and its application
  • A group of markers for predicting the risk of metastasis of nasopharyngeal carcinoma and its application
  • A group of markers for predicting the risk of metastasis of nasopharyngeal carcinoma and its application

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Embodiment Construction

[0021] The technical solution of the present invention will be further described below in combination with experiments.

[0022] Case screening:

[0023] The inventor selected 937 patients as samples of patients with non-metastatic locally advanced nasopharyngeal carcinoma, all of whom received radical radiotherapy. Among them, 56.6% of the patients (530 cases) also received concurrent chemotherapy based on cisplatin. After 68.1 months (interquartile IQR 44.6-84.4), 209 of them developed metastases during the follow-up period.

[0024] The inventors used the Affymetrix Human Gene 2.0 ST expression profile chip to detect 24 cases of high risk of metastasis (no metastasis at first diagnosis, but distant metastasis occurred within 2 years after radical treatment) and 24 cases of low risk of metastasis (no metastasis at first diagnosis, and radical treatment 137 differentially expressed genes were obtained by screening the first-diagnosed biopsy paraffin tissue specimens of pati...

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Abstract

The invention discloses a marker for forecasting nasopharynx cancer transfer risk and an application thereof. The marker comprises ANXA1, CBR3, CLASP1, CXCL10, DCTN1, FNDC3B, LRIG1, FNDC3B, HDLBP, POLR2M, WSB2, WNK1, and YBX3. Molecular tags formed by 13 genetic expression formulas of the marker are capable of reflecting the biological specificity of a nasopharynx cancer patient, more accurately forecasting the transfer risk and prognosis of the nasopharynx cancer patient, and guiding clinical medication better. The forecasting efficiency to distance metastasis free survival is superior to thetraditional N-stage.

Description

technical field [0001] The present invention relates to prognostic markers of nasopharyngeal carcinoma, in particular to a group of markers for predicting the metastasis risk of nasopharyngeal carcinoma and its application. Background technique [0002] 40% of the world's nasopharyngeal carcinoma (NPC) occurs in China, with the highest incidence in southern China such as Guangdong Province. 70% of the patients are already in the middle and late stage when they see a doctor, which seriously threatens the life and health of our people. In recent years, with the application of modern imaging technology and the advancement of intensity-modulated radiation therapy, the local control rate of nasopharyngeal carcinoma has been significantly improved, and distant metastasis has become the main mode of treatment failure. According to literature reports, the distant metastasis rate of nasopharyngeal carcinoma patients after initial radical treatment is as high as 30-40%, and metastatic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/158C12Q2600/166
Inventor 马骏柳娜唐欣然黎映琴孙颖唐玲珑毛燕萍何庆梅杨晓静张磐磐云径平曾敬
Owner SUN YAT SEN UNIV CANCER CENT
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