A strain of Lactobacillus plantarum that improves fat-prone physique and weight of offspring and its application

Abstract

The present invention provides a strain of Lactobacillus plantarum for improving fat-prone physique and progeny body weight and its application. It is preserved in the General Microbiology Center of China Microbiological Culture Collection Management Committee, and the preservation number is CGMCC No.14570. It has excellent acid and bile salt resistance, Bile salt hydrolysis enzyme activity and intestinal colonization ability, animal experiments and human feeding experiments show that the bacteria can control the weight gain of pregnant women and offspring caused by high-fat and high-sugar diet through bile salt hydrolysis enzyme activity and regulation of intestinal flora, and at the same time , the bacterium can regulate the intestinal flora, optimize the structure of the intestinal flora, increase the number of beneficial bacteria, improve the ratio of Bacteroides and Firmicutes, thereby improving obesity-prone physique. Both animal experiments and human food testing experiments have proved that the bacterium has clear efficacy and high safety. It can reverse the fat-prone physique by fundamentally improving the human intestinal flora. The effect is long-lasting and does not rebound, and it has huge market development potential.

Description

technical field [0001] The invention belongs to the technical field of microbes, and more specifically relates to a strain of Lactobacillus plantarum LP-A3 which can control the body weight of parents and offspring and improve obesity-prone physique by regulating intestinal flora and its application. Background technique [0002] With the improvement of people's living standards and changes in lifestyle, the incidence of obesity has risen rapidly. According to the World Health Organization, the number of obese people has doubled since 1980. In 2014, there were 1.9 billion overweight people in the world. [0003] Obesity not only threatens the health of the individual, but also threatens the health of offspring. A large number of studies at home and abroad have shown that obesity during pregnancy is associated with many adverse pregnancy outcomes, such as gestational diabetes, gestational hypertension, dystocia, premature delivery, cesarean section, macrosomia, and prolonge...

AI Technical Summary

Problems solved by technology

However, in the actual use of Lactobacillus plantarum, although some Lactobacillus plantarum can control body weight and regulate fat metabolism, it does not necessarily have a beneficial effect on offspring, nor does it improve the structure of intestinal flora, reverse The role of obesity

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