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Medicinal preparation for treating cervical erosion and use

A pharmaceutical preparation and preparation technology, applied in the field of medicine, can solve problems such as poor curative effect

Inactive Publication Date: 2018-03-30
郭裴哲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the above problems, the present invention provides a pharmaceutical preparation and its application for treating cervical erosion, which can solve the problem of poor curative effect of local drug treatment at present

Method used

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  • Medicinal preparation for treating cervical erosion and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Formula composition: Sucralfate 30g, 5-aminolevulinic acid sodium hydrochloride 45g, carbomer 1g, methyl p-hydroxybenzoate 0.08g, triethanolamine 0.1g, propylene glycol 0.4g, deionized water to 100g.

[0025] Preparation steps: Weigh 1 g of carbomer, disperse it in 60 g of deionized water and swell for 24 hours, then add triethanolamine to adjust the pH value to 4.0-5.0 to obtain solution A; dissolve 0.08 g of methyl p-hydroxybenzoate and 0.4 g of propylene glycol in an appropriate amount of warm water , sucralfate 30g, 5-aminolevulinic acid sodium hydrochloride 45g, and slowly add in the solution A, add deionized water to 100g, stir evenly to obtain the drug gel.

Embodiment 2

[0027] Example 2

[0028] Formula composition: sucralfate 12g, 5-aminolevulinic acid sodium hydrochloride 25g, carbomer 0.5g, methyl p-hydroxybenzoate 0.04g, triethanolamine 0.1g, propylene glycol 0.2g, deionized water to 100g.

[0029] Preparation steps: Weigh 0.5 g of carbomer, disperse it in 40 g of deionized water and swell for 24 hours, then add triethanolamine to adjust the pH value to 4.0-5.0 to obtain solution A; dissolve 0.04 g of methyl p-hydroxybenzoate and 0.2 propylene glycol in appropriate amount of warm water g. Sucralfate 12g, 5-aminolevulinic acid sodium hydrochloride 25g, and slowly add to solution A, add deionized water to 100g, stir evenly to obtain drug gel.

experiment example

[0037] A number of women aged 25-45 who showed different degrees of cervical erosion by colposcopy analysis were selected. Before the treatment started, colposcopy was used to analyze the degree of cervical erosion of each patient. Patients were graded according to conventional cervical pathological classification, and the grading scheme was as follows:

[0038] Grade 1: Simple cervicitis with spotted lesions and ectopia, reduced leucorrhea, no dyspareunia (abnormal pain during intercourse);

[0039] Grade 2: cervicitis with enlarged erosions (30% of the surface), presence of altered epithelium: occasional bleeding and occasional dyspareunia;

[0040] Grade 3: Cervicitis with enlarged erosions (50% of the surface), ectopic presence, frequent bleeding, leucorrhea and dyspareunia.

[0041] After grading, they were divided into 4 groups according to the grading results, and there were 10 patients with grade 1, grade 2, and grade 3 in each group, wherein the first group was admin...

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Abstract

The invention relates to a medicinal preparation for treating cervical erosion and a use of the medicinal preparation for treating the cervical erosion, and the medicinal preparation comprises effective active components of sucralfate and 5-aminolevulinic acid or derivatives of 5-aminolevulinic acid. According to the invention, sucralfate and 5-aminolevulinic acid or the derivatives of 5-aminolevulinic acid are combined to be used as active components of the medicine, and local medication is used for treating the cervical erosion, so that unexpected curative effects are achieved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical preparation for treating cervical erosion and its application. Background technique [0002] Cervical erosion is the most common lesion in gynecological clinics. It is a disease in which the squamous epithelium of the cervix is ​​eroded due to infection or trauma (such as childbirth) and replaced by columnar epithelium. The erosive area of ​​the cervix is ​​prone to inflammation and often leads to increased menstrual discharge. More importantly, cervical erosion requires early treatment to prevent possible malignant changes. In fact, if not treated properly, cervical erosion can easily lead to cervical cancer. According to statistics, about 10% of female deaths due to cancer are caused by cervical cancer. [0003] Cervical erosions are generally treated surgically, usually by cauterization, electrocoagulation, or cryosurgery. Surgical therapy dest...

Claims

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Application Information

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IPC IPC(8): A61K31/7024A61K31/195A61P15/00
CPCA61K31/7024A61K31/195A61K2300/00
Inventor 郭裴哲
Owner 郭裴哲
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