Pharmaceutical composition for treating cervical erosion and application

A composition and drug technology, applied in the field of medicine, can solve problems such as poor curative effect, achieve the effects of increasing blood supply, promoting proliferation, differentiation and secretion, and promoting regeneration

Inactive Publication Date: 2018-01-16
GUILIN HAOXIN TECH SERVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the above problems, the present invention provides a pharmaceutical composition for the treatment of cervic

Method used

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  • Pharmaceutical composition for treating cervical erosion and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Formula composition: dracaena polyphenol 10g, sucralfate 20g, carbomer 0.8g, methyl paraben 0.06g, triethanolamine 0.1g, propylene glycol 0.4g, deionized water to 100g.

[0024] Preparation steps: Weigh 0.8g of carbomer, disperse it in 60g of deionized water and swell for 24 hours, then add triethanolamine to adjust the pH value to 4.0-5.0 to obtain solution A; dissolve 0.06g of methyl p-hydroxybenzoate and 0.4 g. 10 g of dragon's blood polyphenols and 20 g of sucralfate were slowly added to solution A, and deionized water was added to 100 g, and the drug gel was obtained by stirring evenly.

Embodiment 2

[0026] Formula composition: dracaena polyphenol 5g, sucralfate 10g, carbomer 0.4g, methyl paraben 0.05g, triethanolamine 0.1g, propylene glycol 0.2g, deionized water to 100g.

[0027] Preparation steps: Weigh 0.4 g of carbomer, disperse it in 40 g of deionized water and swell for 24 hours, then add triethanolamine to adjust the pH value to 4.0-5.0 to obtain solution A; dissolve 0.03 g of methyl p-hydroxybenzoate and 0.2 propylene glycol in appropriate amount of warm water g. 5 g of dragon's blood polyphenols and 10 g of sucralfate were slowly added to solution A, and deionized water was added to 100 g, and the drug gel was obtained by stirring evenly.

experiment example

[0035] A number of women aged 20-40 who showed different degrees of cervical erosion by colposcopy analysis were selected. Before the treatment started, colposcopy was used to analyze the degree of cervical erosion of each patient. Patients were graded according to conventional cervical pathological classification, and the grading scheme was as follows:

[0036] Grade 1: Simple cervicitis with spotted lesions and ectopia, reduced leucorrhea, no dyspareunia (abnormal pain during intercourse);

[0037] Grade 2: cervicitis with enlarged erosions (30% of the surface), presence of altered epithelium: occasional bleeding and occasional dyspareunia;

[0038] Grade 3: Cervicitis with enlarged erosions (50% of the surface), ectopic presence, frequent bleeding, leucorrhea and dyspareunia.

[0039] After grading, they were divided into 4 groups according to the grading results, and there were 10 patients with grade 1, grade 2, and grade 3 in each group, wherein the first group was admin...

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PUM

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Abstract

The invention relates to a pharmaceutical composition for treating cervical erosion and application. The effective active ingredients of the pharmaceutical composition are dragon's blood polyphenol and sucralfate. According to the pharmaceutical composition provided by the invention, the dragon's blood polyphenol and the sucralfate are combined as the active ingredients of the medicine, and an unexpected curative effect is realized through local application to treat cervical erosion.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating cervical erosion and its application. Background technique [0002] Cervical erosion is the most common lesion in gynecological clinics. It is a disease in which the squamous epithelium of the cervix is ​​eroded due to infection or trauma (such as childbirth) and replaced by columnar epithelium. The erosive area of ​​the cervix is ​​prone to inflammation and often leads to increased menstrual discharge. More importantly, cervical erosion requires early treatment to prevent possible malignant changes. In fact, if not treated properly, cervical erosion can easily lead to cervical cancer. According to statistics, about 10% of female deaths due to cancer are caused by cervical cancer. [0003] Cervical erosions are generally treated surgically, usually by cauterization, electrocoagulation, or cryosurgery. Surgical therapy dest...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P15/00A61K31/7024
Inventor 钟传新王君
Owner GUILIN HAOXIN TECH SERVICE
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