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Novel application method of treating psoriasis by oxymatrine

A technology for oxymatrine and psoriasis, applied in the field of medicine, can solve the problems of large side effects, poor psoriasis effect and the like

Active Publication Date: 2014-04-16
施惠娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the shortcomings of existing medicines and methods for treating psoriasis, such as poor effect and large side effects, and provide a new method of using oxymatrine to treat psoriasis

Method used

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  • Novel application method of treating psoriasis by oxymatrine
  • Novel application method of treating psoriasis by oxymatrine
  • Novel application method of treating psoriasis by oxymatrine

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Embodiment 1, treatment group 50 cases, male 27 cases, female 23 cases, age 20-68 years old, average age 40.32 years old, course of disease 1 month-26 years, average 2.42 years. Oxymatrine injection was used for intravenous infusion, once a day, with a dose of 0.6 g and 100 ml for intravenous infusion, and the course of treatment was four weeks.

Embodiment 2

[0038] Example 2, 53 cases in the combined group, 29 males and 24 females, aged 19-67 years, with an average age of 40.12 years, and a course of disease ranging from 1 month to 24 years, with an average of 2.32 years. Intravenous infusion of oxymatrine was used (the method was the same as in Example 1), and at the same time combined with narrow-band UVB to irradiate the skin of the patient's lesion (using a Waldmann UVB therapeutic device), the initial dose was 0.25J / cm 2 , and then gradually increase according to the skin reaction, generally increase 0.02-0.03 J / cm every 2 times 2 , up to 0.66J / cm 2 , 3 times a week. The course of treatment is also four weeks.

Embodiment 3

[0039] Example 3. There were 50 cases in the irradiation group, 26 males and 24 females, aged 18-65 years, with an average age of 38.24 years, and the course of disease was 1 month-20 years, with an average of 2.02 years. Using simple irradiation, use narrow-band UVB to irradiate the skin of the patient's lesion (using Waldmann UVB treatment device), the initial dose is 0.25J / cm 2 , and then gradually increase according to the skin reaction, generally increase 0.02-0.03 J / cm every 2 times 2 , up to 0.66J / cm 2 , 3 times a week, the course of treatment is also four weeks.

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Abstract

The invention relates to application of a compound oxymatrine to treating psoriasis, and relates to pharmaceutical acceptable form of the oxymatrine and application thereof to treating the psoriasis, and belongs to the field of medicines. The oxymatrine and the form can be used as injection, tablet, capsula, external emulsion and paste agent. The oxymatrine can combine the prior technology for treating the psoriasis such as ultraviolet ray irradiation. The compound oxymatrine can be applied to treating the psoriasis, and the amount of the oxymatrine is 100mg-1000mg. The psoriasis is ordinary psoriasis, erythroderma type psoriasis, pustule type psoriasis and arthrosis type psoriasis or complication caused by each type of psoriasis such as heart and cerebral vessel and metabolism diseases. The oxymatrine also can be applied to each tumour, dermatitis and eczema. The application of oxymatrine to treating psoriasis in the invention can reach an unexpected curative effect and a cure rate more than 80% compared with the prior medicine and drug for treating the psoriasis. This application is an innovation in treating the psoriasis.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to the application method of oxymatrine for treating psoriasis. Background technique [0002] Psoriasis is common disease of dermatology, frequently-occurring disease, still does not have the ideal medicine for the treatment of this disease at present. The etiology and pathogenesis of psoriasis are still unclear, but it is generally believed that psoriasis is a polygenic genetic disease that interacts with multiple factors, and finally causes keratinocytes to proliferate through a common immune-mediated pathway. Psoriasis is generally believed to be related to genetics, immunity, infection, regulation of proliferation and differentiation of keratinocytes, endocrine, neuropsychiatric factors, metabolic disorders, microcirculation, and hemorheology. The pathogenesis of psoriasis is related to bacterial, fungal and viral infections. An important feature of the pathophysiology of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4375
Inventor 施惠娟
Owner 施惠娟
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