Multivalent meningococcus conjugated vaccine and preparation method thereof

Abstract

The invention provides recombinant delta fHbp-NadA fusion protein carrier-based multivalent meningococcocci. Through a flexible linker peptide chain, two active proteins are fused and expressed, activity of the two active proteins is kept and the active proteins are integrated into a single protein so that industrial production and immunization are controllable, a risk is greatly reduced and morepolysaccharide-protein binding sites are provided.

Description

technical field [0001] The invention belongs to the field of biotechnology, in particular to a multivalent meningococcal conjugate vaccine and a preparation method thereof. Background technique [0002] 1. Pathogenic microorganisms and vaccines [0003] Microorganisms that can cause infectious diseases in humans or animals are called pathogenic microorganisms or pathogenic microorganisms. Infection refers to the process of pathogenic microorganisms invading the body, growing and multiplying in certain parts, and causing a series of pathophysiological processes. When pathogenic microorganisms invade the body, the pathogenic microorganisms interact with the body and change each other's activity and function. Therefore, whether they can cause infectious diseases depends on the pathogenicity or virulence of the pathogenic microorganisms on the one hand, and on the other hand. Depends on the body's resistance, that is, immunity. The ability of pathogenic bacteria to cause infe...

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Problems solved by technology

[0017] However, the use of fHbp protein alone also has certain defects, because the expression level of fHbp protein is low in some MenB strains, and a vaccine with only fHbp antigens cannot be used for a wide range of immune meningococcal infections. Fusion expression of multiple antigens may well be a good choice

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