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Application of crocetin in preparation of medicine for preventing and treating polycystic ovary syndrome

A technology of crocetin and polycystic ovary, applied in the field of medicine

Active Publication Date: 2020-03-17
NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no relevant report on the use of crocetin in the treatment of polycystic ovary syndrome.

Method used

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  • Application of crocetin in preparation of medicine for preventing and treating polycystic ovary syndrome
  • Application of crocetin in preparation of medicine for preventing and treating polycystic ovary syndrome
  • Application of crocetin in preparation of medicine for preventing and treating polycystic ovary syndrome

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Experimental program
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Effect test

Embodiment 1

[0019] Example 1 Study on the therapeutic effect of crocetin on dihydrotestosterone-induced polycystic ovary syndrome in mice.

[0020] 1. Experimental materials

[0021] 1.1 Experimental drugs and reagents

[0022] Crocetin was purchased from Shanxi Senfu Natural Products Co., Ltd.

[0023] 1.2 Experimental animals and breeding

[0024] Adult male and female mice (C57Bl / 6J×A / J)F1(B6A) were used in this study, provided by Cavens, certificate number: 201602427. All mice were housed in an SPF grade animal room with 12-hour light and dark cycles at 22–24°C and 55%–65% humidity. free access to water and food.

[0025] 2. Method

[0026] 2.1 Modeling method of dihydrotestosterone-induced polycystic ovary syndrome mouse model

[0027] Male and female mice were housed together, and during the 16-18 days of pregnancy, dihydrotestosterone (250 μg) was subcutaneously injected daily, and mice in the control group were injected with solvent.

[0028] 2.2 Therapeutic effect of croce...

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Abstract

The invention dislcoses application of crocetin in preparation of a drug or a health care product for preventing and treating polycystic ovarian syndrome. On the basis of the existing effects of the crocetin, a foetal period dihydrotestosterone-induced polycystic ovarian syndrome mouse model is adopted to deeply research therapeutic action of the crocetin. Results show that the crocetin can remarkably relieve estrous cycle dysrhythmia of a polycystic ovarian syndrome model mouse, reduce ovary weight and an atresia ovary amount, increasing amounts of corpora lutea big antral follicles and follicles before ovulation, and remarkably improve levels of estradiol, luteinizing hormone, follicle-stimulating hormone, progesterone and testosterone of the polycystic ovarian syndrome model mouse, andhas a good effect of treating the polycystic ovarian syndrome. Moreover, in an experiment process, obviously untoward effects do not appear, and the safety is high.

Description

technical field [0001] The invention relates to a new application of crocetin, a traditional Chinese medicine monomer, for treating polycystic ovary syndrome, and belongs to the technical field of medicine. Background technique [0002] Polycystic ovary syndrome is a common reproductive endocrine disorder affecting 4-8% of women of reproductive age. Its main features are: oligoovulation or anovulation, clinical manifestations of hyperandrogen (hirsutism, acne, etc.) and / or hyperandrogenemia, and polycystic changes in the ovary. Anovulatory bleeding or oligomenorrhea during puberty, ovulation disorder during childbearing period is an important cause of infertility, and diabetes, non-alcoholic fatty liver, hyperlipidemia, hypertension, gestational diabetes, pregnancy-induced hypertension and uterine Risk of endometrial cancer. It is a multi-phenotype, difficult-to-cure disease with both short-term and long-term risks. [0003] At present, hormone-modulating drugs are mainly...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/557A61P15/08A61P15/00
CPCA61K31/557
Inventor 盛亮金晶胡巧云
Owner NANJING MEDICAL UNIV
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