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Application of dioscorea panthaica prain et burk and/or dioscorea nipponica makino steroidal total saponins extract in preparing medicine promoting reverse cholesterol transport

A technology of cholesterol reverse transport and piercing yam, which is applied in the field of medicine and can solve the problems of unrelated research on cholesterol

Pending Publication Date: 2018-06-12
CHENGDU DIAO PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, in the prior art, how to prevent and / or treat diseases related to atherosclerosis for the extract of yellow yam and / or diosgenide total saponins, and the extraction of total saponins of yellow yam and / or diossteroid There is no related research on how drugs promote cholesterol reverse transcription

Method used

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  • Application of dioscorea panthaica prain et burk and/or dioscorea nipponica makino steroidal total saponins extract in preparing medicine promoting reverse cholesterol transport
  • Application of dioscorea panthaica prain et burk and/or dioscorea nipponica makino steroidal total saponins extract in preparing medicine promoting reverse cholesterol transport
  • Application of dioscorea panthaica prain et burk and/or dioscorea nipponica makino steroidal total saponins extract in preparing medicine promoting reverse cholesterol transport

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0164] Example 1 Effect experiment on serum blood lipid level

[0165] The test was carried out with reference to the experimental materials, experimental models under items 1-2 of the preamble of the specific embodiment and the experimental method described in item 2.2.1 "Measurement of serum biochemical indicators".

[0166] ApoE gene deletion is a susceptibility factor for AS, so ApoE- / - mice slowly develop AS lesions during normal diet feeding, LDL-C and TC levels are significantly higher than normal gene mice, and HDL-C also compensates Sexuality rises. On this basis, the AS model group induced by high fat was administered. Compared with the ApoE- / -+ND control group, LDL-C, TC, TG were significantly increased, and HDL-C was significantly decreased; compared with the model group, steroid Both the high and low dose groups of total saponins XXK could significantly increase HDL-C and decrease LDL-C and TC levels (P0.05). The diosgenin group could also raise HDL-C and lower ...

Embodiment 2

[0170] Example 2 Experiment on Effects on Aortic Atherosclerotic Plaque Area

[0171] The test was carried out with reference to the experimental materials, experimental models under items 1-2 of the preamble and the experimental methods described in item 2.2 "observation indicators" and item 2.2.2 "measurement of AS plaque area by oil red O staining".

[0172] After 8 weeks of intragastric administration, compared with the model group, the steroidal total saponins XXK high and low dose groups both significantly reduced the plaque area in the arterial lumen (18.43±3.88%, 24.62±4.86% vs. 42.94±7.15%), and There was a dose-related relationship, and the effect was most obvious in the high-dose group (P figure 2 shown.

Embodiment 3

[0173] Example 3 Effect experiment on cholesterol efflux-related proteins

[0174] Refer to the specific implementation method for the experimental materials and experimental models under the preamble 1-2, and item 2.2.3 "Detection of expression of cholesterol efflux-related proteins ABCA1, ABCG1, and SR-B1 by immunofluorescence staining" and 2.2.4 "Western-blot detection The experimental method described in "Expression of Cholesterol Antitransport-Related Proteins" was carried out.

[0175] Cholesterol reverse transport is an important part of removing cholesterol from the body. The effects of steroidal total saponins XXK on the expression of cholesterol efflux proteins ABCA1, ABCG1 and SR-B1 in AS plaque area were detected. The results of immunofluorescence staining of frozen sections of aortic root tissue showed that compared with the model group, the high and low dose groups of steroidal total saponins XXK could increase the positive expression of ABCA1, ABCG1, and SR-B1 ...

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Abstract

The invention belongs to the field of medicine and specifically discloses application of a dioscoreaceae plant dioscorea panthaica prain et burk and / or dioscorea nipponica makino steroidal total saponins extract in preparing a medicine for promoting reverse cholesterol transport and in preparing a medicine for regulating PPAR(gamma)-LXR(alpha)-ABCA1 gene pathway expression. Furthermore, the invention furtheralso discloses application in preparing medicines for preventing and treating atherosclerosis and medicines for treating the diseases on the pathological basis of atherosclerosis, based onthe effecton the effect basis ofon promoting the reverse cholesterol transport.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of steroidal total saponin extracts of yellow yam and / or Dioscorea punctatus in preparing drugs for promoting cholesterol reverse transport. Background technique [0002] Atherosclerosis (AS) is the primary cause of cardiovascular disease, and it is one of the leading causes of death in many developed countries, and its morbidity and mortality are also increasing year by year in my country. These diseases seriously endanger human health and bring great psychological and economic burdens to patients, family members and society. The occurrence of atherosclerosis is closely related to the increase of body cholesterol level. High-density lipoprotein (HDL) acts as a receptor for cholesterol and transports it from surrounding tissues (including macrophages and AS plaques) to the liver for recycling or excretion as cholic acid, a process known as cholesterol reversal Transp...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P3/06A61P9/10A61P25/28
CPCA61K36/8945
Inventor 董光新李文雯王若竹李伯刚赵海
Owner CHENGDU DIAO PHARMA GROUP
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